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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-MAP3K8 Antibody (pSer334)/SPC-953D-A594/100-µl
商品详细StressMarq/Anti-MAP3K8 Antibody (pSer334)/SPC-953D-A594/100-µl
StressMarq/Anti-MAP3K8 Antibody (pSer334)/SPC-953D-A594/100-µl
StressMarq/Anti-MAP3K8 Antibody (pSer334)/SPC-953D-A594/100-µl
商品编号: SPC-953D-A594
市场价: ¥6840.00
美元价: 4104.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

Product Name MAP3K8 Antibody (pSer334)
Description

Rabbit Anti-Human MAP3K8 (pSer334) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Ser334 of human COT (AA331-337)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 52.898 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-953, RRID: AB_2707553
Certificate of Analysis A 1:250 dilution of SPC-953 was sufficient for detection of MAP3K8 (pSer334) in 10 µg of 293T cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names Cancer Osaka thyroid oncogene Antibody, CCOT Antibody, COT Antibody, EST Antibody, Ewing sarcoma transformant Antibody, M3K8_HUMAN Antibody, MEKK8 Antibody, Mitogen activated protein kinase kinase kinase 8 Antibody, Serine/threonine protein kinase cot Antibody, TPL 2 Antibody, Tumor progression locus 2 Antibody
Research Areas Cancer, Cell Signaling, MAPK Pathway, Protein Phosphorylation, Serine / Threonine Kinases
Cellular Localization Cytoplasm
Accession Number NP_005195
Gene ID 1326
Swiss Prot P41279
Scientific Background MAP3K8 is a protein serine/threonine kinase that can activate both MAPK and JNKK pathways. It is required for TLR4 activation of the MEK/ERK pathway. It can activate NF-kB1 by stimulating the proteolysis of its inhibitor, p105, and promote the production of TNF-alpha and IL-2 during T-cell activation. It has been shown to mediate Raf-inhibiting drug resistance in BRAF(V600E) cell lines. MAP3K8 may also play a role in the cell cycle.

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 ATTO 594
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 1137 g/mol

ATTO 594 Datasheet

 ATTO 594 Fluorophore Excitation and Emission SpectrumOptical Properties:

λex = 601 nm

λem = 627 nm

εmax = 1.2×105

Φf = 0.85

τfl = 3.5 ns

Brightness = 102

Laser = 594 nm

Filter set = Texas Red®

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。