STRESS MARQ/来那度胺/SIH-410-10MG/10MG
商品编号：
SIH-410-10MG
市场价：
¥1500.00
美元价：
900.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Lenalidomide |
| Description | Ubiquitinligaseinducer |
| Purity | >98%(TLC);NMR(Conforms) |
| CASNo. | 191732-72-6 |
| MolecularFormula | C13H13N3O3 |
| MolecularWeight | 259.26 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inducer |
| Solubility | SolubleinDMSO(200mM),Water(<1 mM) and Ethanol (<1 mM). |
| Source | Synthetic |
| Appearance | Powder |
| SMILES | C1=CC=C(C3=C1C(N(C2C(NC(=O)CC2)=O)C3)=O)N |
| InChI | InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) |
| InChIKey | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Acutetoxicity,Oral(Category4),Acutetoxicity,Dermal(Category4),Acutetoxicity,Inhalation(Category4),Reproductivetoxicity(Category1B)SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H301-Harmfulifswallowed.H312-Harmfulincontactwithskin.H332-Harmfulifinhaled.H360-Maydamagefertilityortheunbornchild.Precautionarystatements:P261-Avoidbreathingdust/fumes/gas/mist/vapors/spray.P263-Avoidcontactduringpregnancy/whilenursing.P270-Donoteat,drinkorsmokewhenusingthisproduct.P280-Wearprotectivegloves/protectiveclothing.P301+P310-IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physician.P302+P352-IFONSKIN:Washwithplentyofsoapandwater.P304+P340-IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P308+P313-IFexposedorconcerned:Getmedicaladvice/attention.P330-Rinsemouth.P405-Storelockedup.P501-Disposeofcontents/containertoalicenseddisposalcompany. |
| CiteThisProduct | Lenalidomide(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-410) |
BIOLOGicalDescription
| AlternativeNames | 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione |
| ResearchAreas | CellSignaling,Post-translationalModifications |
| PubChemID | 216326 |
| ScientificBackground | Clinically,lenalidomidehasproventobeeffectiveinthetreatmentofmultiplemyelomaandotherBcelldiseases.IthastheABIlitytoselectivelybindandubiquitinatetwolymphoidtranscriptionfactors,IKZF1andIKZF2,viatheCRBN-CRL4ubiquitinligase.ThisultimatelyleadstothedegradationofIKZF1andIKZF2,whicharebothessentialinmyelomacellsurvival. |
| References | 1.KrönkeJ.,etal.(2014)Science.343(6168):301-5. 2.LuG.,etal.(2014)Science.343(6168):305-9. |
ProductImages
ChemicalstructureofLenalidomide(SIH-410),aUbiquitinligaseinducer.CAS#:191732-72-6.MolecularFormula:C13H13N3O3.MolecularWeight:259.26g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
