StressMarq/Leflunomide/SIH-368-50MG/50-mg
商品编号：
SIH-368-50MG
市场价：
¥860.00
美元价：
516.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Leflunomide |
| Description | Immunosupressant |
| Purity | >98%(TLC:5:95,CH3OH/CH2Cl2;Rf=0.65);NMR(Conforms) |
| CASNo. | 75706-12-6 |
| MolecularFormula | C12H9F3N2O2 |
| MolecularWeight | 270.21 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | MaybedissolvedinDMSO(30mg/ml);orEthanol(27mg/ml) |
| Source | Synthetic |
| Appearance | Whitecrystallinesolid |
| SMILES | CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F |
| InChI | InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) |
| InChIKey | VHOGYURTWQBHIL-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionRiskPhrases:R25–ToxicifswallowedR62–PossIBLeriskofimpairedfertilityR63–PossibleriskofharmtotheunbornchildHazardPhrases:H301–Toxicifswallowed.H315–Causesskinirritation.H319–CausesseriouseyeirritationH335–MaycauserespiratoryirritationPrecautionaryPhrases:P264–WashhandsthoroughlyafterhandlingP280–Wearprotectivegloves/protectiveclothing/eyeprotection/faceprotectionP301+310-IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physicianP308+313-Ifexposedorconcerned:Getmedicaladvice/attention |
| CiteThisProduct | Leflunomide(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-368) |
BIOLOGicalDescription
| AlternativeNames | 5-methyl-N-[4-(trifluoromethyl)phenyl]-isoxazole-4-carboxamide |
| ResearchAreas | CellSignaling,Neuroscience |
| PubChemID | 3899 |
| ScientificBackground | LeflunomideisanImmuno-suppressant,itinhibitsdenovosynthesisofpyrimidinenucleotidesandtheactivityoftheproteinkinase.Itisapartoftheknown“disease-modifyinganti-rheumaticdrugs”(DMARD).Ithasbeensuggestedthatleflunomidemodulatestheexpansionofactivatedautoimmunelymphocytesactingontheregressionofrheumatoidconditions(1-2).Ithasbeenshowntohaveadoublemechanismofactionbyslowingdownandrelievingthepainofrheumatoidarthritis.StudieshaveshownthelethaleffectsofLeflunomideafteradmiNISTrationtomiceinvariousdoses(3). |
| References | 1.FukushimaR.,KanamoriS.,HirashibaM.,etal.(2007)Reprod.Toxical.24(3-4):310-316. 2.SmolenJS.,EmeryP.(2000)Rheumatology.39:48-56. 3.FoxR.I.,HerrmanM.L.,FranqouC.G.,WahlG.M.,MornsR.E.,StrandV.andKirschbaumB.S.(1999)ClinImmunol93(3):198-208. |
ProductImages
ChemicalstructureofLeflunomide(SIH-368),aImmunosupressant.CAS#:75706-12-6.MolecularFormula:C12H9F3N2O2.MolecularWeight:270.21g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
