StressMarq/LDN-57444/SIH-332-10MG/10-mg
商品编号：
SIH-332-10MG
市场价：
¥2040.00
美元价：
1224.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | LDN-57444 |
| Description | DUB inhibitor |
| Purity | >98% |
| CAS No. | 668467-91-2 |
| Molecular Formula | C17H11Cl3N2O3 |
| Molecular Weight | 397.6 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 20 mg/ml DMSO |
| Source | Synthetic |
| Appearance | Yellow Powder |
| SMILES | CC(=O)O/N=C1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl |
| InChI | InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16- |
| InChIKey | OPQRFPHLZZPCCH-PGMHBOJBSA-N |
| Safety Phrases | Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed H317 – May cause an allergic skin reaction Precautionary Statements: P280 – Wear protective gloves. |
| Cite This Product | LDN-57444 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-332) |
Biological Description
| Alternative Names | 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444 |
| Research Areas | Cancer, Apoptosis |
| PubChem ID | 16760696 |
| Scientific Background | Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable. |
| References |
1. Liu Y., et al. (2003) Chem. Biol. 10: 837. 2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109. 3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857. |
Product Images
Chemical structure of LDN-57444 (SIH-332), a DUB inhibitor. CAS #: 668467-91-2. Molecular Formula: C17H11Cl3N2O3. Molecular Weight: 397.6 g/mol.
Product Citations (0)
Currently there are no citations for this product.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
