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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-LATS1 Antibody (pSer909)/SPC-1005D-A565/100-µl
商品详细StressMarq/Anti-LATS1 Antibody (pSer909)/SPC-1005D-A565/100-µl
StressMarq/Anti-LATS1 Antibody (pSer909)/SPC-1005D-A565/100-µl
StressMarq/Anti-LATS1 Antibody (pSer909)/SPC-1005D-A565/100-µl
商品编号： SPC-1005D-A565
市场价： ¥6840.00
美元价： 4104.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name LATS1 Antibody (pSer909)
Description

Rabbit Anti-Human LATS1 (pSer909) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Ser909 of human LATS1 (AA906-912)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 126.87 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-1005, RRID: AB_2708489
Certificate of Analysis A 1:250 dilution of SPC-1005 was sufficient for detection of LATS1 (pSer909) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names h-warts Antibody, Large tumor suppressor homolog 1 Antibody, LATS large tumor suppressor homolog 1 Antibody, LATS1 Antibody, Serine threonine protein kinase LATS1 Antibody, WARTS Antibody, WARTS protein kinase Antibody, wts Antibody
Cellular Localization Cytoplasm, Cytoskeleton
Accession Number NP_004681
Gene ID 9113
Swiss Prot O95835
Scientific Background LATS1 is a protein serine/threonine kinase that suppresses tumour progression by restricting proliferation and promoting apoptosis by activating the transcription of BAX, caspase 3 and p53. It can phosphorylate and inactivate the YAP1 oncoprotein and inhibit its translocation to the nucleus for transcription of genes important for proliferation and migration. LATS1 also negatively regulates the G2/M transition by downregulating CDK1 kinase activity. M669I and R806P mutations have been associated with lung adenocarcinoma and lung large cell carcinoma, respectively. Decreased LATS1 expression due to hypermethylation of the promoter have been associated with breast cancer, acute lymphoblastic leukemia, ovarian cancer, and astrocytoma. However, the very low frequency of reported somatic mutations in this protein indicates that it may function as a tumour requiring protein (TRP) in many human tumours.

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 ATTO 565
Overview:

  • High fluorescence yield
  • High thermal and photostability
  • Good solubility in polar solvents
  • Excellent solubility in water
  • Very little aggregation
  • Rhodamine dye derivative
  • Molar Mass: 611 g/mol

ATTO 565 Datasheet

 ATTO 565 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 563 nm

λem = 592 nm

εmax = 1.2×105

Φf = 0.9

τfl = 3.4 n

Brightness = 10

Laser = 532 nm

Filter set = TRITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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