StressMarq/Lapatinib/SIH-459-50MG/50-mg
商品编号：
SIH-459-50MG
市场价：
¥5000.00
美元价：
3000.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Lapatinib |
| Description | EGFR,HER2inhibitor |
| Purity | >99% |
| CASNo. | 231277-92-2 |
| MolecularFormula | C29H26ClFN4O4S |
| MolecularWeight | 581.1 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubilityinwateris0.007mg/mlandin0.1NHClis0.001mg/mlat25°C |
| Source | Synthetic |
| Appearance | Yellowcrystallinesolid |
| SMILES | C2=C1C(=NC=NC1=CC=C2C3=CC=C(O3)CNCC[S](=O)(=O)C)NC4=CC=C(C(=C4)Cl)OCC5=CC=CC(=C5)F |
| InChI | InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35 |
| InChIKey | BCFGMOOMADDAQU-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Notahazardoussubstanceormixture.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
| CiteThisProduct | Lapatinib(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-459) |
BIOLOGicalDescription
| AlternativeNames | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,GrowthFactorReceptorInhibitors |
| PubChemID | 208908 |
| ScientificBackground | Lapatinibisatyrosinekinaseinhibitor.Specifically,itinterruptstheErbB/neuandepidermalgrowthfactorreceptor(EGFR)pathways.Itisanantineoplasticagentusedinbreastcancerresearch.Insolidtumorcells,LapatinibbindstotheATP-bindingpocketoftheproteinkinasedomainsonEGFR/ErbB,preventingself-phosphorylation. |
| References | 1.ChienA.J.,etal.(2014)J.Clin.Oncol:J.Am.Clin.Oncol.32(14):1472–1479. 2.DahalB.K.,etal.(2010)Am.J.Resp.CriticalCareMed.181(2):158–167. |
ProductImages
ChemicalstructureofLapatinib(SIH-459),aEGFRandHER2inhibitor.CAS#:231277-92-2.MolecularFormula:C29H26ClFN4O4S.MolecularWeight:581.1g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
