StressMarq/KT5720/SIH-457-500UG/500-µg
商品编号：
SIH-457-500UG
市场价：
¥9000.00
美元价：
5400.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | KT5720 |
| Description | PKAkinaseinhibitor |
| Purity | >98%(TLC) |
| CASNo. | 108068-98-0 |
| MolecularFormula | C32H31N3O5 |
| MolecularWeight | 537.6 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleinmethanol:clearcolorlesssolutionat5mg/ml |
| Source | Synthetic |
| Appearance | Whitepowder |
| SMILES | [N]47C1=C(C6=C(C2=C1[N](C3=CC=CC=C23)[[email protected]]5O[[email protected]@]4([[email protected]](C5)(O)C(=O)OCCCCCC)C)C(NC6)=O)C8=C7C=CC=C8 |
| InChI | InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,3 |
| InChIKey | ZHEHVZXPFVXKEY-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Specifictargetorgantoxicity-singleexposure(Category1),H370SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H370Causesdamagetoorgans.Precautionarystatements:P260Donotbreathedust/fume/gas/mist/vapours/spray.P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P307+P311IFexposed:CallaPOISONCENTERordoctor/physician.P321Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant |
| CiteThisProduct | KT5720(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-457) |
BIOLOGicalDescription
| AlternativeNames | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacidhexylester |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 3844 |
| ScientificBackground | KT5720isapotentandselectiveinhibitorofproteinkinaseA(PKA).ThiscompoundblocksPKAsignalingthroughcompetitiveinhibition.ItcausesnosignificanteffectonproteinkinaseC(PKC),proteinkinaseG(PKG)ormyosinlightchainkinase(mlCK).KT5720hasbeenshowntoreversIBLyarrestshumanskinfibroblastsintheG1phase.Itiscellpermeable. |
| References | 1.KaseH.,etal.(1987)Biochem.Biophys.Res.Comm.142(2):436–440. 2.GadboisD.M.,CrissmanH.A.,TobeyR.A.,&BradburyE.M.(1992)Pro.Na.Aca.Sci.USA.89(18):8626–8630. |
ProductImages
ChemicalstructureofKT5720(SIH-457),aPKAkinaseinhibitor.CAS#:108068-98-0.MolecularFormula:C32H31N3O5.MolecularWeight:537.6g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
