StressMarq/KT5720/SIH-457-100UG/100-µg
商品编号：
SIH-457-100UG
市场价：
¥2500.00
美元价：
1500.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | KT5720 |
| Description | PKA kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 108068-98-0 |
| Molecular Formula | C32H31N3O5 |
| Molecular Weight | 537.6 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in methanol: clear colorless solution at 5 mg/ml |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | [N]47C1=C(C6=C(C2=C1[N](C3=CC=CC=C23)[[email protected]]5O[[email protected]@]4([[email protected]](C5)(O)C(=O)OCCCCCC)C)C(NC6)=O)C8=C7C=CC=C8 |
| InChI | InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,3 |
| InChIKey | ZHEHVZXPFVXKEY-UHFFFAOYSA-N |
| Safety Phrases | Classification: Specific target organ toxicity-single exposure (Category 1), H370Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.Hazard statements: H370 Causes damage to organs.Precautionary statements: P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | KT5720 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-457) |
Biological Description
| Alternative Names | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester |
| Research Areas | Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 3844 |
| Scientific Background | KT5720 is a potent and selective inhibitor of protein kinase A (PKA). This compound blocks PKA signaling through competitive inhibition. It causes no significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (mlCK). KT5720 has been shown to reversibly arrests human skin fibroblasts in the G1 phase. It is cell permeable. |
| References |
1. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440. 2. Gadbois D.M., Crissman H.A., Tobey R.A., & Bradbury E.M. (1992) Pro. Na. Aca. Sci. USA. 89(18): 8626–8630. |
Product Images
Chemical structure of KT5720 (SIH-457), a PKA kinase inhibitor. CAS #: 108068-98-0. Molecular Formula: C32H31N3O5. Molecular Weight: 537.6 g/mol.
Product Citations (0)
Currently there are no citations for this product.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
