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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/K252B/SIH-456-1MG/1-mg
商品详细StressMarq/K252B/SIH-456-1MG/1-mg
StressMarq/K252B/SIH-456-1MG/1-mg
StressMarq/K252B/SIH-456-1MG/1-mg
商品编号: SIH-456-1MG
市场价: ¥9000.00
美元价: 5400.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

Product Name K252B
Description

Kinase inhibitor

Purity >98% (HPLC)
CAS No. 99570-78-2
Molecular Formula C26H19N3O5
Molecular Weight 453.5

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml)
Source Synthetic
Appearance White solid
SMILES C[[email protected]]12[[email protected]@](C[[email protected]](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
InChI InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1
InChIKey AMSOPBXQXSAAAC-PLZPTFKGSA-N
Safety Phrases Classification: Flammable liquids (Category 4), H227Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.Hazard statements: H227 Combustible liquidPrecautionary statements: P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol - resistant foam for extinction. P403 + P235 Store in a well - ventilated place. Keep cool. P501 Dispose of contents/ container to an approved waste disposal plant
Cite This Product K252B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-456)

Biological Description

Alternative Names (9S,​10R,​12R)-​2,​3,​9,​10,​11,​12-​hexahydro-​10-​hydroxy-​9-​methyl-​1-​oxo-​9,​12-​epoxy-​1H-​diindolo[1,​2,​3-​fg:3',​2',​1'-​kl]pyrrolo[3,​4-​i][1,​6]benzodiazocine-​10-​carboxylic acid
Research Areas Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 9981344
Scientific Background K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.
References 1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071.
2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969.
3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.

Product Images

<p>Chemical structure of K252B (SIH-456), a Kinase inhibitor (pan-specific). CAS #: 99570-78-2. Molecular Formula: C26H19N3O5. Molecular Weight: 453.5 g/mol.</p>

Chemical structure of K252B (SIH-456), a Kinase inhibitor (pan-specific). CAS #: 99570-78-2. Molecular Formula: C26H19N3O5. Molecular Weight: 453.5 g/mol.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。