StressMarq/J9/SIH-182-10MG/10-mg
商品编号：
SIH-182-10MG
市场价：
¥2500.00
美元价：
1500.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | J9 |
| Description | Glucocorticoidresistanceinhibitor |
| Purity | 99.90% |
| MolecularFormula | C12H12N4 |
| MolecularWeight | 212.26 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | BlueIceor4ºC |
| ProductType | Inhibitor |
| Solubility | SolubleinCDCI3 |
| Source | Synthetic |
| Appearance | WhiteSolid |
| SMILES | NC1=NC(C2CC2)=C(C3=CC=NC=C3)C=N1 |
| InChI | InChI=1S/C12H12N4/c13-12-15-7-10(8-3-5-14-6-4-8)11(16-12)9-1-2-9/h4-7,9H,1-2H2,(H2,13,15,16) |
| InChIKey | PQLYPFZAOUDDHB-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | J9(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-182) |
BIOLOGicalDescription
| AlternativeNames | 4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine |
| ResearchAreas | Cancer,CellSignaling,Epigenetics |
| PubChemID | PMC4094258 |
| ScientificBackground | J9,incombinationwithdexamethasoneinhibitscellgrowthinT-cellacutelymphoblasticleukemia(T-ALL)throughtheupregulationoftheglucocorticoidreceptor.Patientscandevelopglucocorticoidresistancerenderingthetreatmentineffective.J9anditsmechanismofactionprovidesausefulstrategyforovercomingtheresistance.TheEC50ofJ9incombinationwithdexamethasoneis28uM.J9alonewaslesstoxic. |
| References | 1.CantleyA.M.,etal.(2014)ACSMedicinalChemistryLetters5.7:754-759. |
ProductImages
ChemicalstructureofJ9(SIH-182),aGlucocorticoidresistanceinhibitor.CAS#:.MolecularFormula:C12H12N4.MolecularWeight:212.26g/mol.
ProductCitations(0)
Currentlytherearenocitationsforthisproduct.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
