StressMarq/Irinotecan HCl/SIH-243-250MG/250-mg
商品编号：
SIH-243-250MG
市场价：
¥7400.00
美元价：
4440.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | IrinotecanHCl |
| Description | TopoisomeraseIinhibitor |
| Purity | >98% |
| CASNo. | 100286-90-6 |
| MolecularFormula | C33H38N4O6•HCl |
| MolecularWeight | 623.14 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inducer |
| Solubility | Solubleto50mg/mlinDMSO |
| Source | Synthetic |
| Appearance | Yellowsolid |
| SMILES | CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[[email protected]@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7 |
| InChI | InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)1 |
| InChIKey | UWKQSNNFCGGAFS-XIFFEERXSA-N |
| SafetyPhrases | Classification:Harmful.Maybeharmfulifinhaled,swallowedorabsorbedthroughskin.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS45-Incaseofaccidentorifyoufeelunwell,seekmedicaladviceimmediately(showthelabelwherepossIBLe)RiskPhrases:R20/21/22-Harmfulbyinhilation,incontactwithskinandifswallowedR62-PossibleriskofimpairedfertilityR68-PossibleriskofirreversibleeffectsHazardPhrases:H302 |
| CiteThisProduct | IrinotecanHCl(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-243) |
BIOLOGicalDescription
| AlternativeNames | (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3",4":6,7]indolizino[1,2-b]quinolin-9-yl1,4"-bipiperidine-1"-carboxylate,CPT11,Camptothecin11 |
| ResearchAreas | Cancer,Apoptosis |
| PubChemID | 74990 |
| ScientificBackground | Irinotecanisatopoisomerase1inhibitor,whichpreventsDNAfromunwinding.Chemicallyitisasemisyntheticanalogueofthenaturalalkaloidcamptothecin.ItisactivatedbyhydrolysistoSN-38whichistheninactivatedbyglucuronidationbyUGT1A1.ThisinactivationeventuallyleadstoinhibitionofbothDNAreplicationandtranscription(1,2). |
| References | 1.InnocentriF.,etal.(2004)JClin.Oncol.22(8):1382-1388. 2.O’DwyerP.J.,andCatalanoR.B.(2006)JClinOncol.24(28):4534-4538. |
ProductImages
ChemicalstructureofIrinotecanHCl(SIH-243),aTopoisomeraseIinhibitor.CAS#:100286-90-6.MolecularFormula:C33H38N4O6.HCl.MolecularWeight:623.14g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
