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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Irinotecan HCl/SIH-243-50MG/50-mg
商品详细StressMarq/Irinotecan HCl/SIH-243-50MG/50-mg
StressMarq/Irinotecan HCl/SIH-243-50MG/50-mg
StressMarq/Irinotecan HCl/SIH-243-50MG/50-mg
商品编号: SIH-243-50MG
市场价: ¥2040.00
美元价: 1224.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameIrinotecanHCl
Description

TopoisomeraseIinhibitor

Purity>98%
CASNo.100286-90-6
MolecularFormulaC33H38N4O6•HCl
MolecularWeight623.14

Properties

StorageTemperature-20ºC
ShippingTemperatureShippedAmbient
ProductTypeInducer
SolubilitySolubleto50mg/mlinDMSO
SourceSynthetic
AppearanceYellowsolid
SMILESCCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[[email protected]@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
InChIInChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)1
InChIKeyUWKQSNNFCGGAFS-XIFFEERXSA-N
SafetyPhrasesClassification:Harmful.Maybeharmfulifinhaled,swallowedorabsorbedthroughskin.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS45-Incaseofaccidentorifyoufeelunwell,seekmedicaladviceimmediately(showthelabelwherepossIBLe)RiskPhrases:R20/21/22-Harmfulbyinhilation,incontactwithskinandifswallowedR62-PossibleriskofimpairedfertilityR68-PossibleriskofirreversibleeffectsHazardPhrases:H302
CiteThisProductIrinotecanHCl(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-243)

BIOLOGicalDescription

AlternativeNames(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3",4":6,7]indolizino[1,2-b]quinolin-9-yl1,4"-bipiperidine-1"-carboxylate,CPT11,Camptothecin11
ResearchAreasCancer,Apoptosis
PubChemID74990
ScientificBackgroundIrinotecanisatopoisomerase1inhibitor,whichpreventsDNAfromunwinding.Chemicallyitisasemisyntheticanalogueofthenaturalalkaloidcamptothecin.ItisactivatedbyhydrolysistoSN-38whichistheninactivatedbyglucuronidationbyUGT1A1.ThisinactivationeventuallyleadstoinhibitionofbothDNAreplicationandtranscription(1,2).
References1.InnocentriF.,etal.(2004)JClin.Oncol.22(8):1382-1388.
2.O’DwyerP.J.,andCatalanoR.B.(2006)JClinOncol.24(28):4534-4538.

ProductImages

<p>Chemical structure of Irinotecan HCl (SIH-243), a Topoisomerase I inhibitor. CAS #: 100286-90-6. Molecular Formula: C33H38N4O6.HCl. Molecular Weight: 623.14 g/mol.</p>

ChemicalstructureofIrinotecanHCl(SIH-243),aTopoisomeraseIinhibitor.CAS#:100286-90-6.MolecularFormula:C33H38N4O6.HCl.MolecularWeight:623.14g/mol.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。