StressMarq/ICG-001/SIH-387-5MG/5-mg
商品编号：
SIH-387-5MG
市场价：
¥2580.00
美元价：
1548.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | ICG-001 |
| Description | β-catenininhibitor |
| Purity | >98% |
| CASNo. | 847591-62-2 |
| MolecularFormula | C33H32N4O4 |
| MolecularWeight | 548.63 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleto100mMinDMSOandto50mMinethanol |
| Source | Synthetic |
| Appearance | Whitesolid |
| SMILES | C1CN([[email protected]]2CN(C(=O)[[email protected]@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6 |
| InChI | InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/ |
| InChIKey | HQWTUOLCGKIECB-XZWHSSHBSA-N |
| SafetyPhrases | Classification:Caution.Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-Avoidcontactwithskinandeyes |
| CiteThisProduct | ICG-001(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-387) |
BIOLOGicalDescription
| AlternativeNames | (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide |
| ResearchAreas | CellSignaling |
| PubChemID | 11238147 |
| ScientificBackground | InhibitorofTCF/β-catenin-mediatedtranscription.Selectivelyinhibitsβ-catenin/CBPinteraction;displaysnoeffectonβ-catenin/p300interaction.Exhibitsgrowthinhibitoryeffectsincoloncarcinomacelllines(SW480andHCT-116cells);alsodisplaysefficacyinMinmouseandnudemouseSW620xenograftmodels. |
| References | 1.EmamiK.H.,etal.(2004)Proc.Natl.Acad.Sci.USA.101(34):12682-7. 2.DeSousaE.M.,etal.(2011)Clin.CancerRes.17(4):647-53. 3.ZhouB.,etal.(2012)J.Biol.Chem.287(10):7026-38. |
ProductImages
ChemicalstructureofICG-001(SIH-387),abeta-catenin/CBPinhibitor.CAS#:847591-62-2.MolecularFormula:C33H32N4O4.MolecularWeight:548.63g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
