StressMarq/Hydroxychloroquine/SIH-400-50MG/50-mg
商品编号：
SIH-400-50MG
市场价：
¥5900.00
美元价：
3540.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | Hydroxychloroquine |
| Description | Autophagy inhibitor |
| Purity | >98% |
| CAS No. | 747-36-4 |
| Molecular Formula | C18H26ClN3O•H2SO4 |
| Molecular Weight | 433.95 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in greater than 20 mg/ml H2O. |
| Source | Synthetic |
| Appearance | White to off-white powder. |
| SMILES | C1=C2C(=CC(=C1)Cl)N=CC=C2NC(CCCN(CCO)CC)C.O=[S](O)(O)=O |
| InChI | InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4) |
| InChIKey | JCBIVZZPXRZKTI-UHFFFAOYSA-N |
| Safety Phrases | Classification: Acute toxicity, Oral (Category 4), Eye irritation (Category 2A) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H319- Causes serious eye irritation. Precautionary statements: P264- Wash skin thoroughly after handling. P270- Do not eat, drink or smoke when using this product. P280- Wear protective gloves/ eye protection/ face protection. P301 + P312- IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P330- Rinse mouth. P337 + P313- If eye irritation persists: Get medical advice/ attention. P501- Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Hydroxychloroquine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-400) |
Biological Description
| Alternative Names | Hydroxychloroquine sulphate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline |
| Research Areas | Cancer, Autophagy |
| PubChem ID | 12947 |
| Scientific Background | Hydroxychloroquine was first established as an anti-malarial agent, but is now being used in a variety of applications, including the inhibition of autopagy. Hydroxychloroquine is a lysosomotropic agent and therefore inhibits autophagy by obstructing the final step of autophagy, the fusion of autophagosomes with lysosomes, thereby preventing the acidification of the lysosomal compartment. In the context of cancer, autophagy is thought to be adopted by tumor cells to survive in the nutrient-deficient and hypoxic tumor environment. Hydroxychloroquine has therefore been studied extensively within the context of certain cancers. |
| References |
1. van Loosdregt J., et al. (2013) J Allergy Clin Immunol. 131(5): 1443-6.e1. 2. Lotze M.T., et al. (2013) Cancer J. 19(4): 341-7. 3. Xie X., et al. (2013) PLoS One. 8(1): e55096. |
Product Images
Chemical structure of Hydroxychloroquine (SIH-400), a Autophagy inhibitor. CAS #: 747-36-4. Molecular Formula: C18H26ClN3O · H2SO4. Molecular Weight: 433.95 g/mol.
Product Citations (0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
