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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/HSP90 Protein/SPR-122A/50-µg
商品详细StressMarq/HSP90 Protein/SPR-122A/50-µg
StressMarq/HSP90 Protein/SPR-122A/50-µg
StressMarq/HSP90 Protein/SPR-122A/50-µg
商品编号: SPR-122A
市场价: ¥3200.00
美元价: 1920.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameHSP90Protein
Description

P.FalciparumRecombinantHSP90PartialProtein

ApplicationsWB,SDS-PAGE
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesNotag

Properties

StorageBuffer50mMTris/HClpH7.5,300mMNaCl,10%glycerol
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
Specificity~234kDa
CiteThisProductPlasmodiumfalciparumRecombinantHSP90Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-122)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDS-PAGEanalysis.

BIOLOGicalDescription

AlternativeNamesPfHSP90Protein,Pf14_-417HSP90Protein,HSP90Protein
ResearchAreasCancer,HeatShock
CellularLocalizationCytoplasm,Melanosome
AccessionNumberXP_001348591.1
GeneID811999
SwissProtQ8IL32
ScientificBackgroundHSP90isanabundantlyandubiquitouslyexpressedheatshockprotein.Itisunderstoodtoexistintwoprincipalformsalphaandbeta,whichshare85%sequenceaminoacidhomology.ThetwoisoformsofHSP90areexpressedinthecytosoliccompartment(1).Despitethesimilarities,HSP90alphaexistspredominantlyasahomodimerwhileHSP90betaexistsmainlyasamonomer(2).Fromafunctionalperspective,HSP90participatesinthefolding,assembly,maturation,andstABIlizationofspecificproteinsasanintegralcomponentofachaperonecomplex(3-6).FurThermore,HSP90ishighlyconservedbetweenspecies;having60%and78%aminoacidsimilaritybetweenmammalianandthecorrespondingyeastandDrosophilaproteins,respectively.HSP90isahighlyconservedandessentialstressproteinthatisexpressedinalleukaryoticcells.Despiteitslabelofbeingaheat-shockprotein,HSP90isoneofthemosthighlyexpressedproteinsinunstressedcells(1-2%ofcytosolicprotein).Itcarriesoutanumberofhousekeepingfunctions,includingcontrollingtheactivity,turnover,andtraffickingofavarietyofproteins.MostoftheHSP90-regulatedproteinsthathavebeendiscoveredtodateareinvolvedincellsignaling(7-8).ThenumberofproteinsnowknowtointeractwithHSP90isabout100.Targetproteinsincludethekinasesv-Src,Wee1,andc-Raf,transcriptionalregulatorssuchasp53andsteroidreceptors,andthepolymerasesofthehepatitisBvirusandtelomerase(5).WhenboundtoATP,HSP90interactswithco-chaperonesCdc37,p23,andanassortmentofimmunophilin-likeproteins,formingacomplexthatstabilizesandprotectstargetproteinsfromproteasomaldegradation.Inmostcases,HSP90-interactingproteinshavebeenshowntoco-precipitatewithHSP90whencarryingoutimmuneadsorptionstudies,andtoexistincytosolicheterocomplexeswithit.Inanumberofcases,variationsinHSP90expressionorHSP90mutationhasbeenshowntodegradesignalingfunctionviatheproteinortoimpairaspecificfunctionoftheprotein(suchassteroidbinding,kinaseactivity)invivo.Ansamycinantibiotics,suchasgeldanamycinandrADIcicol,inhibitHSP90function(9).Recently,Prof.Tatu’slaboratoryhasshowntheimportanceofHSP90inparasitegrowth.TheyhaveshownthatinhibitionofP.FalciparumHSP90(PfHSP90),blockstheerythrocyticcyclebyinhibitingstagetransformation,leadingtoinhibitionofparasitegrowth(10,11).LookingformoreinformationonHSP90?VisitournewHSP90ScientificResourceGuideathttp://www.HSP90.ca.
References1.NemotoT.,etal.(1997)J.BiolChem.272:26179-26187.
2.MinamiY.,etal.(1991)J.BiolChem.266:10099-10103.
3.ArlanderS.J.H,etal.(2003)JBiolChem.278:52572-52577.
4.PearlH.,etal.(2001)AdvProteinChem.59:157-186.
5.NeckersL.,etal.(2002)TrendsMolMed.8:S55-S61.
6.PrattW.,ToftD.(2003)ExpBiolMed.228:111-133.
7.PrattW.,ToftD.(1997)EndocrRev.18:306–360.
8.PrattW.B.(1998)ProcSocExptlBiolMed.217:420–434.
9.WhitesellL.,etal.(1994)ProcNatlAcadSciUSA.91:8324–8328.
10.BanumathyG.,SinghV.,PavithraS.R.,andTatuU.(2003)JBiolChem.278(20):18336-45.
11.PavithraS.R,BanumathyG.,JoyO.,SinghV.,andTatuU.(2004)JBiolChem.279(45):46692-9.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。