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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/抗HSP70/HSC70（植物）抗体/SPC-312D/100-µl
商品详细StressMarq/抗HSP70/HSC70（植物）抗体/SPC-312D/100-µl
StressMarq/抗HSP70/HSC70（植物）抗体/SPC-312D/100-µl
StressMarq/抗HSP70/HSC70（植物）抗体/SPC-312D/100-µl
商品编号： SPC-312D
市场价： ¥6160.00
美元价： 3696.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name HSP70/HSC70 (Plant) Antibody
Description

Rabbit Anti-HSP70/HSC70 (Plant) Polyclonal

Species Reactivity Arabidopsis thaliana, Barley (Hordeum vulgare L.), Fish, Lettuce (Lactuca sativa), Mammals, Plant, Radish (Raphanus sativus)
Applications WB
Antibody Dilution WB (1:1000), IP (1:1000); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen KLH-conjugated synthetic peptide conserved in all known sequences of HSP70 and HSC70 proteins
Conjugates Unconjugated

Properties

Storage Buffer Lyophilized rabbit Antiserum. For reconstitution add 100 µl of sterile water.
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Rabbit antiserum
Clonality Polyclonal
Specificity Detects ~70kDa.
Cite This Product StressMarq Biosciences Cat# SPC-312, RRID: AB_1501444
Certificate of Analysis 0.1 µl/ml of SPC-312 was sufficient for detection of HSP70/HSC70 in 1 mg wet plant sample extract by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names HSC54 Antibody, HSC71 Antibody, HSC73 Antibody, HSP71 Antibody, HSP73 Antibody, HSPA10 Antibody, HSPA8 Antibody, LAP1 Antibody, NIP71 Antibody, HSC70 Antibody
Research Areas Cancer, Heat Shock
Cellular Localization Cytoplasm
Scientific Background HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (1). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (2). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (3). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (4). When cells are subjected to metabolic stress (e.g., heat shock) a member of the HSP 70 family, HSP 70 (HSP72), is expressed; HSP 70 is highly related to HSC70 (>90% sequence identity). Constitutively expressed HSC70 rapidly forms a stable complex with the highly inducible HSP70 in cells following heat shock. The interaction of HSC70 with HSP 70 is regulated by ATP. These two heat shock proteins move together in the cell experiencing stress. Furthermore, research on HSC70 has implicates it with a role in facilitating the recovery of centrosomal structure and function after heat shock (5). Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References 1. Boorstein W.R., Ziegelhoffer T., and Craig E.A. (1993) J. Mol. Evol. 38(1): 1-17.
2. Rothman J. (1989) Cell. 59: 591-601.
3. DeLuca-Flaherty et al. (1990) Cell. 62: 875-887.
4. Bork P., Sander C., and Valencia A. (1992) Proc. Natl Acad. Sci. USA. 89: 7290-7294.
5. Brown C.L. et al. (1996) J. Biol. Chem. 271(2): 833-840.

Product Images

<p>Western blot analysis of Rat (1) and Human (2) Tissue lysates showing detection of HSP70 protein using Rabbit Anti-HSP70 Polyclonal Antibody (SPC-312). Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody (SPC-312) at 1:1000.</p>

Western blot analysis of Rat (1) and Human (2) Tissue lysates showing detection of HSP70 protein using Rabbit Anti-HSP70 Polyclonal Antibody (SPC-312). Primary Antibody: Rabbit Anti-HSP70 Polyclonal Antibody (SPC-312) at 1:1000.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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CLIA套件 兴奋剂 敌手 抑制剂 蛋白质 活化剂 抗氧化剂 氧化还原探针 多克隆
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