4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-HSP70/HSC70 (pan) Antibody/SPC-311D/100-µg
商品详细StressMarq/Anti-HSP70/HSC70 (pan) Antibody/SPC-311D/100-µg
StressMarq/Anti-HSP70/HSC70 (pan) Antibody/SPC-311D/100-µg
StressMarq/Anti-HSP70/HSC70 (pan) Antibody/SPC-311D/100-µg
商品编号: SPC-311D
市场价: ¥6360.00
美元价: 3816.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameHSP70/HSC70(pan)Antibody
Description

RabbitAnti-HSP70/HSC70(pan)Polyclonal

SpeciesReactivityArABIdopsisthaliana,Bacteria,Fish,Fungi,Lettuce(Lactucasativa),Mammals,Plant,RADIsh(Raphanussativus),X.Bacteria(Xylellafastidiosa)-9a5cstrain
ApplicationsWB
AntibodyDilutionWB(1:1000),IP(1:1000);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenKLH-conjugatedsyntheticpeptideconservedinallknownHSP70andHSC70proteins
ConjugatesUnconjugated

Properties

StorageBufferLyophilized,PBSpH7.4.Forreconstitutionadd100µlofsterilewater.
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationProteinApurified
ClonalityPolyclonal
SpecificityDetects~70kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-311,RRID:AB_2120315
CertificateofAnalysis1µg/mlofSPC-311wassufficientfordetectionofHSP70/HSC70in1mgwetplantsampleextractbycolorimetricimmunoblotanalysisusingGoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesHSC54Antibody,HSC71Antibody,HSC73Antibody,HSP71Antibody,HSP73Antibody,HSPA10Antibody,HSPA8Antibody,LAP1Antibody,NIP71Antibody,HSC70Antibody
ResearchAreasCancer,HeatShock
CellularLocalizationCytoplasm
ScientificBackgroundHSP70genesencodeabundantheat-inducible70-kDaHSPs(HSP70s).InmosteukaryotesHSP70genesexistaspartofamultigenefamily.Theyarefoundinmostcellularcompartmentsofeukaryotesincludingnuclei,mitochondria,chloroplasts,theendoplasmicreticulumandthecytosol,aswellasinbacteria.Thegenesshowahighdegreeofconservation,havingatleast5O%identity(1).TheN-terminaltwothirdsofHSP70saremoreconservedthantheC-terminalthird.HSP70bindsATPwithhighaffinityandpossessesaweakATPaseactivitywhichcanbestimulatedbybindingtounfoldedproteinsandsyntheticpeptides(2).WhenHSC70(constitutivelyexpressed)presentinmammaliancellswastruncated,ATPbindingactivitywasfoundtoresideinanN-terminalfragmentof44kDawhichlackedpeptidebindingcapacity.PolypeptidebindingabilitythereforeresidedwithintheC-terminalhalf(3).ThestructureofthisATPbindingdomaindisplaysmultiplefeaturesofnucleotidebindingproteins(4).Whencellsaresubjectedtometabolicstress(e.g.,heatshock)amemberoftheHSP70family,HSP70(HSP72),isexpressed;HSP70ishighlyrelatedtoHSC70(>90%sequenceidentity).ConstitutivelyexpressedHSC70rapidlyformsastablecomplexwiththehighlyinducIBLeHSP70incellsfollowingheatshock.TheinteractionofHSC70withHSP70isregulatedbyATP.Thesetwoheatshockproteinsmovetogetherinthecellexperiencingstress.FurThermore,researchonHSC70hasimplicatesitwitharoleinfacilitatingtherecoveryofcentrosomalstructureandfunctionafterheatshock(5).LookingformoreinformationonHSP70?VisitournewHSP70ScientificResourceGuideathttp://www.HSP70.com.
References1.BoorsteinW.R.,ZiegelhofferT.,andCraigE.A.(1993)J.Mol.Evol.38(1):1-17.
2.RothmanJ.(1989)Cell.59:591-601.
3.DeLuca-Flahertyetal.(1990)Cell.62:875-887.
4.BorkP.,SanderC.,andValenciaA.(1992)Proc.NatlAcad.Sci.USA.89:7290-7294.
5.BrownC.L.etal.(1996)J.Biol.Chem.271(2):833-840.

ProductImages

Currentlytherearenoimagesforthisproduct

ProductCitations(1)

WesternBlot

CharacterizationoftheTolB-Paltrans-envelopecomplexfromXylellafastidiosarevealsadynamicandcoordinatedproteinexpressionprofileduringthebiofilmdevelopmentprocess.

Santos,C.A.etal.(2015)BiochimBiophysActa.1854(10PtA):1372-1381.

PubMedID:26049080ReactivityX.fastidiosa9a5cstrainApplications:WesternBlot

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。