STRESTMARQ/抗HSP70抗体[C92F3A-5]/SMC-100B-A700/200-微克-免疫在线蚂蚁淘旗下平台

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商品详细STRESTMARQ/抗HSP70抗体[C92F3A-5]/SMC-100B-A700/200-微克

STRESTMARQ/抗HSP70抗体[C92F3A-5]/SMC-100B-A700/200-微克

商品编号： SMC-100B-A700

品牌： StressMarq Biosciences

市场价： ¥8120.00

美元价： 4872.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Overview:

ProductName HSP70Antibody

Description

MouseAnti-HumanHSP70MonoclonalIgG

SpeciesReactivity Dog,Human,Monkey,Mouse,Rat,Bovine,Carp(Cypriniformes),Chicken,FruitFly(Drosophilamelanogaster),GuineaPig(Caviaporcellus),Hamster,Nematode(CaenorhaBDitiselegans),Pig,Rabbit,Sheep

Applications WB,IHC,ICC/IF,ELISA,FCM,FACS,IEM,Bl,AM

AntibodyDilution WB(1:1000),IHC(1:10000),ICC/IF(1:1000),FACS(1:1000);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Mouse

ImmunogenSpecies Human

Immunogen HumanHSP70

Concentration 1mg/ml

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

PerCP

Overview:

Peridinin-Chlorophyll-ProteinComplex
Smallphycobiliprotein
Isolatedfromredalgae
Largestokesshift(195nm)
MolecularWeight:35kDa

PerCPDatasheet

PerCP Fluorophore Absorption and Emission Spectrum

OpticalProperties:

λ_ex =482nm

λ_em=677nm

ε_max=1.96x10⁶

Laser =488nm

PE/ATTO594

PE/ATTO594isatandemconjugate,wherePEisexcitedat535nmandtransfersenergytoATTO594viaFRET(fluorescenceresonanceenergytransfer),whichemitsat627nm.

Overview:

Highfluorescenceyield
HighphotostABIlity
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation

PE/ATTO594Datasheet

PE-ATTO 594 Fluorophore Conjugate Excitation and Emission Spectra

OpticalProperties:

λ_ex =535nm

λ_em =627 nm

Laser = 488to561nm

FITC(Fluorescein)

Overview:

Excellentfluorescencequantumyield
Highrateofphotobleaching
Goodsolubilityinwater
Broademissionspectrum
pHdependentspectra
Molecularformula:C₂₀H₁₂O₅
Molarmass:332.3g/mol

FITC-Fluorescent-conjugate

FITC Fluorescein Fluorophore Excitation and Emission Spectra

OpticalProperties:

λ_ex =494 nm

λ_em=520 nm

ε_max=7.3×10⁴

Φ_f= 0.92

τ_fl =5.0ns

Brightness= 67.2

Laser = 488 nm

Filterset = FITC

ATTO700

Overview:

Highfluorescenceyield
Excellentthermalandphotostability
Quenchedbyelectrondonors
Veryhydrophilic
Goodsolubilityinpolarsolvents
Zwitterionicdye
MolarMass:575g/mol

ATTO700Datasheet

ATTO 700 Fluorophore Absorption and Emission Spectrum

OpticalProperties:

λ_ex =700 nm

λ_em=719nm

ε_max=1.25×10⁵

Φ_f= 0.25

τ_fl =1.6ns

Brightness= 31.3

Laser =676nm

Filterset =Cy®5.5

ATTO680

Overview:

Highfluorescenceyield
Excellentthermalandphotostability
Quenchedbyelectrondonors
Veryhydrophilic
Goodsolubilityinpolarsolvents
Zwitterionicdye
MolarMass:631g/mol

ATTO680Datasheet

ATTO 680 Fluorophore Absorption and Emission Spectrum

OpticalProperties:

λ_ex =680nm

λ_em=700 nm

ε_max=1.25×10⁵

Φ_f= 0.30

τ_fl =1.7ns

Brightness=37.5

Laser =633 –676nm

Filterset =Cy®5.5

ATTO655

Overview:

Highfluorescenceyield
Highthermalandphotostability
Excellentozoneresistance
Quenchedbyelectrondonors
Veryhydrophilic
Goodsolubilityinpolarsolvents
Zwitterionicdye
MolarMass:634g/mol

ATTO655Datasheet

ATTO 655 Fluorophore Absorption and Emission Spectrum

OpticalProperties:

λ_ex =663nm

λ_em=684nm

ε_max=1.25×10⁵

Φ_f= 0.30

τ_fl =1.8ns

Brightness= 37.5

Laser =633 –647nm

Filterset =Cy®5

ATTO633

Overview:

Highfluorescenceyield
Highthermalandphotostability
Moderatelyhydrophilic
Goodsolubilityinpolarsolvents
StableatpH4–11
Cationicdye,perchloratesalt
MolarMass:652.2g/mol

ATTO633Datasheet

ATTO 633 Fluorophore Absorption and Emission Spectrum

OpticalProperties:

λ_ex =629nm

λ_em=657nm

ε_max=1.3×10⁵

Φ_f= 0.64

τ_fl =3.2ns

Brightness=83.2

Laser =633 nm

Filterset =Cy®5

ATTO594

Overview:

Highfluorescenceyield
Highphotostability
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation
Newdyewithnetchargeof-1
MolarMass:1137g/mol

ATTO594Datasheet

ATTO 594 Fluorophore Excitation and Emission Spectrum

OpticalProperties:

λ_ex =601 nm

λ_em=627nm

ε_max=1.2×10⁵

Φ_f= 0.85

τ_fl =3.5ns

Brightness=102

Laser =594nm

Filterset =TexasRed®

ATTO565

Overview:

Highfluorescenceyield
Highthermalandphotostability
Goodsolubilityinpolarsolvents
Excellentsolubilityinwater
Verylittleaggregation
Rhodaminedyederivative
MolarMass:611g/mol

ATTO565Datasheet

ATTO 565 Fluorophore Excitation and Emission Spectra

OpticalProperties:

λ_ex =563nm

λ_em=592nm

ε_max=1.2×10⁵

Φ_f= 0.9

τ_fl =3.4n

Brightness=10

Laser =532nm

Filterset = TRITC

ATTO488

Overview:

Highfluorescenceyield
Highphotostability
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation
Newdyewithnetchargeof-1
MolarMass:804g/mol

ATTO488Datasheet

ATTO 488 Fluorophore Excitation and Emission Spectra

OpticalProperties:

λ_ex =501nm

λ_em=523nm

ε_max=9.0×10⁴

Φ_f= 0.80

τ_fl =4.1ns

Brightness= 72

Laser = 488 nm

Filterset = FITC

ATTO390

Overview:

Highfluorescenceyield
LargeStokes-shift(89nm)
Goodphotostability
Moderatelyhydrophilic
Goodsolubilityinpolarsolvents
Coumarinderivate,uncharged
Lowmolarmass:343.42g/mol

ATTO390Datasheet

ATTO 390 Fluorescent Dye Excitation and Emission Spectra

OpticalProperties:

λ_ex =390nm

λ_em=479nm

ε_max=2.4×10⁴

Φ_f= 0.90

τ_fl =5.0ns

Brightness= 21.6

Laser =365or405nm

APC(Allophycocyanin)

Overview:

Highquantumyield
Largephycobiliprotein
6chromophorespermolecule
Isolatedfromredalgae
MolecularWeight:105kDa

APCDatasheet

APC Fluorophore Absorption and Emission Spectrum

OpticalProperties:

λ_ex =650nm

λ_em=660nm

ε_max=7.0×10⁵

Φ_f= 0.68

Brightness= 476

Laser =594or633 nm

Filterset =Cy®5

Streptavidin

Properties:

Homo-tetramericproteinpurifiedfromStreptomycesavidiniiwhichbindsfourbiotinmoleculeswithextremelyhighaffinity
Molecularweight:53kDa
Formula:C₁₀H₁₆N₂O₃S
Applications:Westernblot,immunohistochemistry,andELISA

StreptavidinDatasheet

Biotin

Properties:

BindstetramericavidinproteinsincludingStreptavidinandneuravidinwithveryhighaffinity
Molarmass:244.31g/mol
Formula:C₁₀H₁₆N₂O₃S
Applications:Westernblot,immunohistochemistry,andELISA

BiotinDatasheet

HRP(HorserADIshperoxidase)

Properties:

Enzymaticactivityisusedtoamplifyweaksignalsandincreasevisibilityofatarget
Readilycombineswithhydrogenperoxide(H₂O₂)toformHRP-H₂O₂complexwhichcanoxidizevarioushydrogendonors
Catalyzestheconversionof:
- Chromogenicsubstrates(e.g.TMB,DAB,ABTS)intocolouredproducts
- Chemiluminescentsubstrates(e.g.luminolandisoluminol)intolightemittingproductsviaenhancedchemiluminescence(ECL)
- Fluorogenicsubstrates(e.g.tyramine,homovanillicacid,and4-hydroxyphenylaceticacid)intofluorescentproducts
Highturnoverrateenablesrapidgenerationofastrongsignal
44kDaglycoprotein
Extinctioncoefficient:100(403nm)
Applications:Westernblot,immunohistochemistry,andELISA

HRPDatasheet

AP(AlkalinePhosphatase)

Properties:

Broadenzymaticactivityforphosphateestersofalcohols,amines,pyrophosphate,andphenols
Commonlyusedtodephosphorylatethe5’-terminiofDNAandRNAtopreventself-ligation
Catalyzestheconversionof:
- Chromogenicsubstrates(e.g.pNPP,naphtholAS-TRphosphate,BCIP)intocolouredproducts
- Fluorogenicsubstrates(e.g.4-methylumbelliferylphosphate)intofluorescentproducts
Molecularweight:140kDa
Applications:Westernblot,immunohistochemistry,andELISA

APDatasheet

R-PE(R-Phycoerythrin)

Overview:

Broadexcitationspectrum
Highquantumyield
Photostable
Memberofthephycobiliproteinfamily
Isolatedfromredalgae
Excellentsolubilityinwater
MolecularWeight:250kDa

R-PEDatasheet

R-PE Fluorophore Excitation and Emission Spectra

OpticalProperties:

λ_ex =565nm

λ_em=575nm

ε_max=2.0×10⁶

Φ_f= 0.84

Brightness=1.68x10³

Laser = 488to561nm

Filterset = TRITC

Properties

StorageBuffer	PBSpH7.4,50%glycerol,0.1%sodiumazide
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	ProteinGPurified
Clonality	Monoclonal
CloneNumber	C92F3A-5
Isotype	IgG
Specificity	Detects~70kDa.Doesnotcross-reactwithHSC70(HSP73).
CiteThisProduct	StressMarqBiosciencesCat#SMC-100,RRID:AB_854199
CertificateofAnalysis	1µg/mlofSMC-100wassufficientfordetectionofHSP70in20µgofheatshockedHeLacelllysatebycolorimetricimmunoblotanalysisusingGoatanti-mouseIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	HSP701Antibody,HSP702Antibody,HSP70.1Antibody,HSP72Antibody,HSPA1Antibody,HSPA1AAntibody,HSPA1BAntibody
ResearchAreas	Cancer,HeatShock
CellularLocalization	Cytoplasm
AccessionNumber	NP_005336.3
GeneID	3303
SwissProt	P08107
ScientificBackground	HSP70genesencodeabundantheat-inducIBLe70-kDaHSPs(HSP70s).InmosteukaryotesHSP70genesexistaspartofamultigenefamily.Theyarefoundinmostcellularcompartmentsofeukaryotesincludingnuclei,mitochondria,chloroplasts,theendoplasmicreticulumandthecytosol,aswellasinbacteria.Thegenesshowahighdegreeofconservation,havingatleast50%identity(2).TheN-terminaltwothirdsofHSP70saremoreconservedthantheC-terminalthird.HSP70bindsATPwithhighaffinityandpossessesaweakATPaseactivitywhichcanbestimulatedbybindingtounfoldedproteinsandsyntheticpeptides(3).WhenHSC70(constitutivelyexpressed)presentinmammaliancellswastruncated,ATPbindingactivitywasfoundtoresideinanN-terminalfragmentof44kDawhichlackedpeptidebindingcapacity.PolypeptidebindingabilitythereforeresidedwithintheC-terminalhalf(4).ThestructureofthisATPbindingdomaindisplaysmultiplefeaturesofnucleotidebindingproteins(5).AllHSP70s,regardlessoflocation,bindproteins,particularlyunfoldedones.ThemolecularchaperonesoftheHSP70familyrecognizeandbindtonascentpolypeptidechainsaswellaspartiallyfoldedintermediatesofproteinspreventingtheiraggregationandmisfolding.ThebindingofATPtriggersacriticalconformationalchangeleadingtothereleaseoftheboundsubstrateprotein(6).TheuniversalabilityofHSP70stoundergocyclesofbindingtoandreleasefromhydrophobicstretchesofpartiallyunfoldedproteinsdeterminestheirroleinagreatvarietyofvitalintracellularfunctionssuchasproteinsynthesis,proteinfoldingandoligomerizationandproteintransport.FormoreinformationvisitourHSP70ScientificResourceGuideathttp://www.HSP70.com.
References	1.WelchW.J.andSuhanJ.P.(1986)JCellBiol.103:2035-2050. 2.BoorsteinW.R.,ZiegelhofferT.&CraigE.A.(1993)J.Mol.Evol.38(1):1-17. 3.RothmanJ.(1989)Cell59:591-601. 4.DeLuca-Flahertyetal.(1990)Cell62:875-887. 5.BorkP.,SanderC.&ValenciaA.(1992)Proc.Nut1Acad.Sci.USA89:7290-7294. 6.FinkA.L.(1999)Physiol.Rev.79:425-449. 7.GalanA.,etal.(2000)J.Biol.Chem.275:11418-11424. 8.KondoT.,etal.(2000)J.Biol.Chem.275:8872-8879. 9.MisakiT.,etal.(1994)Clin.Exp.Immun.98:234-239. 10.PockleyA.G.,etal.(1998)Immunol.Invest.27:367-377. 11.MoonI.S.,etal.(2001)CerebCortex11(3):238-248. 12.Dresseletal.(2000)J.Immunol.164:2362-2371. 13.VermaA.K.,etal.(2007)FishandShellfishImmunology.22(5):547-555. 14.BanduseelaV.C.,etal.(2009)PhysiolGenomics.39(3):141-159.

ProductImages

<p>Immunohistochemistry analysis using Mouse Anti-Hsp70 Monoclonal Antibody, Clone C92 (SMC-100). Tissue: colon carcinoma. Species: Mouse. Fixation: Formalin. Primary Antibody: Mouse Anti-Hsp70 Monoclonal Antibody (SMC-100) at 1:10000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Mouse at 1:2000 for 1 hour at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 200 µl for 2 minutes at RT. Localization: Inflammatory cells. Magnification: 40x.</p>

ImmunohistochemistryanalysisusingMouseAnti-Hsp70MonoclonalAntibody,CloneC92(SMC-100).Tissue:coloncarcinoma.Species:Mouse.Fixation:Formalin.PrimaryAntibody:MouseAnti-Hsp70MonoclonalAntibody(SMC-100)at1:10000for12hoursat4°C.SecondaryAntibody:BiotinGoatAnti-Mouseat1:2000for1houratRT.Counterstain:MayerHematoxylin(purple/blue)nuclearstainat200µlfor2minutesatRT.Localization:Inflammatorycells.Magnification:40x.

<p>Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Hsp70 Monoclonal Antibody, Clone C92 (SMC-100). Tissue: Heat Shocked Melanoma cells. Species: Mouse. Fixation: Formalin. Primary Antibody: Mouse Anti-Hsp70 Monoclonal Antibody (SMC-100) at 1:1000 for 16 hours at RT. Secondary Antibody: Biotin Goat Anti-Mouse. Courtesy of: Dr. Ewa Malusecka, Maria Sklodowska-Curie Memorial Cancer Ceter and Inst. Of Oncology, Poland.</p>

Immunocytochemistry/ImmunofluorescenceanalysisusingMouseAnti-Hsp70MonoclonalAntibody,CloneC92(SMC-100).Tissue:HeatShockedMelanomacells.Species:Mouse.Fixation:Formalin.PrimaryAntibody:MouseAnti-Hsp70MonoclonalAntibody(SMC-100)at1:1000for16hoursatRT.SecondaryAntibody:BiotinGoatAnti-Mouse.Courtesyof:Dr.EwaMalusecka,MariaSklodowska-CurieMemorialCancerCeterandInst.OfOncology,Poland.

<p>Immunohistochemistry analysis using Mouse Anti-Hsp70 Monoclonal Antibody, Clone C92 (SMC-100). Tissue: colon carcinoma. Species: Human. Fixation: Formalin. Primary Antibody: Mouse Anti-Hsp70 Monoclonal Antibody (SMC-100) at 1:10000 for 12 hours at 4°C. Secondary Antibody: Biotin Goat Anti-Mouse at 1:2000 for 1 hour at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 200 µl for 2 minutes at RT. Localization: Inflammatory cells. Magnification: 40x.</p>

ImmunohistochemistryanalysisusingMouseAnti-Hsp70MonoclonalAntibody,CloneC92(SMC-100).Tissue:coloncarcinoma.Species:Human.Fixation:Formalin.PrimaryAntibody:MouseAnti-Hsp70MonoclonalAntibody(SMC-100)at1:10000for12hoursat4°C.SecondaryAntibody:BiotinGoatAnti-Mouseat1:2000for1houratRT.Counterstain:MayerHematoxylin(purple/blue)nuclearstainat200µlfor2minutesatRT.Localization:Inflammatorycells.Magnification:40x.

<p>Western Blot analysis of Human cell lysates from various cell lines showing detection of Hsp70 protein using Mouse Anti-Hsp70 Monoclonal Antibody, Clone C92 (SMC-100). Load: 15 µg protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Hsp70 Monoclonal Antibody (SMC-100) at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.</p>

WesternBlotanalysisofHumancelllysatesfromvariouscelllinesshowingdetectionofHsp70proteinusingMouseAnti-Hsp70MonoclonalAntibody,CloneC92(SMC-100).Load:15µgprotein.Block:1.5%BSAfor30minutesatRT.PrimaryAntibody:MouseAnti-Hsp70MonoclonalAntibody(SMC-100)at1:1000for2hoursatRT.SecondaryAntibody:SheepAnti-MouseIgG:HRPfor1houratRT.

<p>Fluorescence Activated Cell Sorting analysis using Mouse Anti-Hsp70: FITC Monoclonal Antibody, Clone C92 (SMC-100). Tissue: Heat Shocked CD3+ CD8+ T cells . Species: Mouse. Primary Antibody: Mouse Anti-Hsp70: FITC Monoclonal Antibody (SMC-100) at 1:1000. Courtesy of: Cheryl Cameron, Vaccine and Gene Therapy Instit. Florida.</p>

FluorescenceActivatedCellSortinganalysisusingMouseAnti-Hsp70:FITCMonoclonalAntibody,CloneC92(SMC-100).Tissue:HeatShockedCD3+CD8+Tcells.Species:Mouse.PrimaryAntibody:MouseAnti-Hsp70:FITCMonoclonalAntibody(SMC-100)at1:1000.Courtesyof:CherylCameron,VaccineandGeneTherapyInstit.Florida.

ProductCitations(56)

WesternBlot

Abrogationofheatshockfactor1(Hsf1)phosphorylationderegulatesitsactivityandlowersactivationthreshold,leadingtoobesityinmice.

Jin,X.,Qiao,A.,Moskophidis,D.andMivechi,N.F.(2017)JBiolChem.[Epubaheadofprint].

PubMedID:28724629ReactivityMouseApplications:WesternBlot

ThetranscriptionalregulatorofthechaperoneresponseHSF1controlshepaticbioenergeticsandproteinhomeostasis.

Qiao,A.,Jin,X.,Pang,J.,Moskophidis,D.andMivechi,N.f.(2017)JCellBiol.216(3):723-741.

PubMedID:28183717ReactivityMouseApplications:WesternBlot

TRIM32-Cytoplasmic-BodyFormationIsanATP-ConsumingProcessStimulatedbyHSP70inCells.

Kawaguchi,Y.etal.(2017)PLoSOne.12(1):e0169436.

PubMedID:28052117ReactivityHumanApplications:WesternBlot

Heatshockprotein90ensuresefficientmumpsvirusreplicationbyassistingwithviralpolymerasecomplexformation

Katoh,H.etal.(2017)JVirol.pii:JVI.02220-16.

PubMedID:28053100ReactivityHumanApplications:WesternBlot

SenkyunolideIattenuatesoxygen-glucosedeprivation/reoxygenation-inducedinflammationinmicroglialcells.

Hu,Y.Y.etal.(2016)BrainRes.1649(PtA):123-131.

PubMedID:27524398ReactivityMouseApplications:WesternBlot

EffectsofLong-TermExposureto60GHzMillimeter-WavelengthRadiationontheGenotoxicityandHeatShockProtein(Hsp)ExpressionofCellsDerivedfromHumanEye.

Koyama,S.etal.(2016)IntJEnvironResPublicHealth.13(8).pii:E802.

PubMedID:27509516ReactivityHumanApplications:WesternBlot

TwentyFour-HourExposuretoa0.12THzElectromagneticFieldDoesNotAffecttheGenotoxicity,MorphologicalChanges,orExpressionofHeatShockProteininHCE-TCells.

Koyama,S.etal.(2016)IntJEnvironResPublicHealth.13(8).pii:E802.

PubMedID:27527204ReactivityHumanApplications:WesternBlot

HeatShockFactor1isaSubstrateforp38Mitogen-ActivatedProteinKinases.

DayalanNaidu,S.etal.(2016)MolCellBiol.36(18):2403-17.

PubMedID:27354066ReactivityHumanApplications:WesternBlot

ExpressionofHeatShockProteinsinHumanFibroblastCellsunderMagneticResonantCouplingWirelessPowerTransfer.

Mizuno,K.,Shinohara,N.andMiyakoshi,J.(2015)Energise.8(10):12020-12028.

PubMedID:N/AReactivityHumanApplications:WesternBlot

CriticalIllnessMyopathy:Understandingdifferenteffectsonmusclefibrefunction.

Ogilvie,H.(2015)KarolinskaInstitutet.PhDDissertation.

PubMedID:N/AReactivityRatApplications:WesternBlot

Heatshockprotein70regulatesdegradationofthemumpsvirusphosphoproteinviatheubiquitin-proteasomepathway.

Katoh,H.etal.(2014)JVirol.89(6):3188-99.

PubMedID:25552722ReactivityHumanApplications:WesternBlot

Heat-inducedexpressionoftheimmediate-earlygeneIER5anditsinvolvementintheproliferationofheat-shockedcells.

Ishikawa,Y.andSakurai,H.(2014)FEBSJ.282(2):332-40.

PubMedID:25355627ReactivityHumanApplications:WesternBlot

ProstaglandinESynthaseInteractswithInducibleHeatShockProtein70AfterHeatStressinBovinePrimaryDermalFibroblastCells.

Richter,C.,Viergutz,T.,Schwerin,M.andWeitzel,J.M.(2014)CytometryA.87(1):61-7.

PubMedID:25412999ReactivityBovineApplications:WesternBlot

Inhibitionofautophagy,lysosomeandVCPfunctionimpairsstressgranuleassembly.

Seguin,S.J.etal.(2014)CellDeathDiffer.21(12):1838-51.

PubMedID:25034784ReactivityHumanApplications:WesternBlot

FastingEnhancesTRAIL-MediatedLiverNaturalKillerCellActivityviaHSP70Upregulation.

Dang,V.T.A.etal.(2014)PLoSOne.9(10):e110748.

PubMedID:25356750ReactivityMouseApplications:WesternBlot

DirectbindingoftheAlubindingproteindimerSRP9/14to40SribosomalsubunitspromotesstressgranuleformationandisregulatedbyAluRNA

Berger,A.etal.(2014)NucleicAcidsRes.42(17):11203-17.

PubMedID:25200073ReactivityHumanApplications:WesternBlot

TherapeuticInducersoftheHSP70/HSP110ProtectMiceAgainstTraumaticBrainInjury.

Eroglu,B.etal.(2014)JNeuRochem.130(5):626-41.

PubMedID:24903326ReactivityMouseApplications:WesternBlot

Acardiopulmonarybypasswithdeephypothermiccirculatoryarrestratmodelfortheinvestigationofthesystemicinflammationresponseandinducedorgandamage.

Engels,M.etal.(2014)JInflamm.11(26).

PubMedID:25400510ReactivityRatApplications:WesternBlot

ModerateAlcoholInducesStressProteinsHSF1andhsp70andInhibitsProinflammatoryCytokinesResultinginEndotoxinTolerance.

Muralidharan,S.etal.(2014)JImmunol.193(4):1975-87.

PubMedID:25024384ReactivityHumanApplications:WesternBlot

Massetermusclemyofibrillarproteinsynthesisanddegradationinanexperimentalcriticalillnessmyopathymodel.

Akkad,H.,Corpeno,R.,LarssonL.(2014)PLoSOne.9(4):e92622.

PubMedID:24705179ReactivityRatApplications:WesternBlot

Structure-ActivityRelationshipsforWithanolidesasInducersoftheCellularHeat-ShockResponse.

Wijeratne,E.M.,etal.(2014)JMedChem.57(7):2851-63.

PubMedID:24625088ReactivityMouseApplications:WesternBlot

DetectionofconstitutiveandinducibleHSP70proteinsinformalinfixedhumanbraintissue.

Preusse-Prange,A.,Modrow,J.H.,Schwark,T.,vonWurmb-Schwark,N.(2014)ForensicSciInt.235:62-7.

PubMedID:24447452ReactivityHumanApplications:WesternBlot

OverexpressionofHeatShockProtein72AttenuatesNF-κBActivationUsingaCombinationofRegulatoryMechanismsinMicroglia.

Sheppard,P.W.,Sun,X.,Khammash,M.,Giffard,R.G.(2014)PLoSComputBiol.10(2):e1003471.

PubMedID:24516376ReactivityMouseApplications:WesternBlot

Effectsofcorticosteroidsinthedevelopmentoflimbmuscleweaknessinaporcineintensivecareunitmodel.

Aare,S.etal.(2013)PhysiolGenomics.45(8):312-320.

PubMedID:23429211ReactivityPigApplications:WesternBlot

IronmodulatescellsurvivalinaRas-andMAPK-dependentmannerinovariancells.

Bauckman,K.A.,Haller,E.,Flores.I.,andNanjundan,M.(2013)CellDeathDis.4.e592.

PubMedID:23598404ReactivityHumanApplications:WesternBlot

MolecularandCellularNetworksinCriticalIllnessAssociatedMuscleWeakness:SkeletalMuscleProteostasisintheIntensiveCareUnit.

Banduseela,V.C.(2012)UppsalaUniversity,DisciplinaryDomainofMedicineandPharmacy,FacultyofMedicine,DepartmentofNeuroscience.PhDDissertation

PubMedID:N/AReactivityPigApplications:WesternBlot

Influencesoftemperature,oxidativestress,andphosphorylationonbindingofheatshockproteinsinskeletalmusclefibers.

Larkins,N.T.,Murphy,R.M.,andLamb,G.D.(2012)AmJPhysiolCellPhysiol.303(6):C654-C665.

PubMedID:22763123ReactivityRatApplications:WesternBlot

DnaJA1AntagonizesConstitutiveHsp70-MediatedStabilizationofTau.

Abisambra,J.F.,etal.(2012)J.Mol.Biol.421:653-661.

PubMedID:22343013ReactivityHumanApplications:WesternBlot

Hsp70PromotesEpithelialSodiumChannelFunctionalExpressionbyIncreasingItsAssociationwithCoatComplexIIandItsExitfromEndoplasmicReticulum.

Chanoux,R.A.etal.(2012)JBiolChem.287,19255-19265.

PubMedID:22496374ReactivityDogApplications:WesternBlot

UsingtheHeat-ShockResponseToDiscoverAnticancerCompoundsthatTargetProteinHomeostasis.

Santagata,S.etal.(2012)ACSChem.Biol.7(2):340-349.

PubMedID:22050377ReactivityHumanApplications:WesternBlot

AbsoluteamountsanddiffusibilityofHSP72,HSP25,andαB-crystallininfast-andslow-twitchskeletalmusclefibersofrat.

Larkins,N.T.,Murphy,R.M.,andLamb,G.D.(2011)AmJPhysiolCellPhysiol.302(1):C228-C239.

PubMedID:21975426ReactivityRatApplications:WesternBlot

Mechanismsunderlyingthesparingofmasticatoryversuslimbmusclefunctioninanexperimentalcriticalillnessmodel.

Aare,S.etal.(2011)PhysiolGenomics.43(24):1334-1350.

PubMedID:22010006ReactivityPigApplications:WesternBlot

HeatShockProtein70PreventsbothTauAggregationandtheInhibitoryEffectsofPreexistingTauAggregatesonFastAxonalTransport.

Patterson,K.R.etal.(2011)Biochem.50(47):10300-10310.

PubMedID:22039833ReactivityHumanApplications:WesternBlot

WithaferinAAnalogsandUsesThereof.

Gunatilaka,L.,Lindquist,S.L.,Whitesell,L.,Wijeratne,E.M.K.,andXu,Y.(2011)UnitedStatesPatentApplicationUS20110230551A1.

PubMedID:N/AReactivityMouseApplications:WesternBlot

Preferentialskeletalmusclemyosinlossinresponsetomechanicalsilencinginanovelratintensivecareunitmodel:underlyingmechanisms.

Ochala,J.etal.(2011)JPhysio.589(8):2007-2026.

PubMedID:21320889ReactivityRatApplications:WesternBlot

Co-overexpressionofBag-1andheatshockprotein70inhumanepidermalsquamouscellcarcinoma:Bag-1-mediatedresistanceto5-fluorouracilinducedapoptosis.

Wood,J.etal.(2011)BrJCancer.104(9):1459-1471.

PubMedID:21522149ReactivityHumanApplications:WesternBlot

EffectsofHSP70onthecompressionforce-inducedTNF-αandRANKLexpressioninhumanperiodontalligamentcells.

Mitsuhashi,M.,Yamaguchi,M.,Kojima,T.,Nakajima,R.,Kasai,K.(2011)InflammationResearch.60(2):187-194.

PubMedID:20924639ReactivityHumanApplications:WesternBlot

DecipheringHumanHeatShockTranscriptionFactor1RegulationviaPost-TranslationalModificationinYeast.

Batista-Nascimento,L.,Neef,D.W.,Liu,P.C.C.,Rodrigues-Pousada,C.,Thiele,D.J.(2011)PLoSOne.6(1):e15976.

PubMedID:21253609ReactivityMouseApplications:WesternBlot

DecipheringHumanHeatShockTranscriptionFactor1RegulationviaPost-TranslationalModificationinYeast.

Batista-Nascimento,L.,Neef,D.W.,Liu,P.C.C.,Rodrigues-Pousada,C.,Thiele,D.J.(2011)PLoSOne.6(1):e15976.

PubMedID:21253609ReactivityHumanApplications:WesternBlot

Tamm-Horsfallproteinandurinaryexosomeisolation.

Fernández-Llama,P.etal.(2010)KidneyInt.77,736-742.

PubMedID:20130532ReactivityHumanApplications:WesternBlot

GeneexpressionandmusclefiberfunctioninaporcineICUmodel.

Banduseela,V.C.etal.(2009)PhysiolGenomics.39(3):141-159.

PubMedID:19706692ReactivityPigApplications:WesternBlot

2,3-DihydrowithaferinA-3β-O-sulfate,anewpotentialprodrugofwithaferinAfromaeroponicallygrownWithaniasomnifera.

Xu,Y.etal.(2009)BioorgMedChem.17(6):2210-2214.

PubMedID:19056281ReactivityMouseApplications:WesternBlot

IdentificationofPhosphorylation-DependentBindingPartnersofAquaporin-2UsingProteinMassSpectrometry.

Zwang,N.A.etal.(2009)J.ProteomeRes.8(3):1540-1554.

PubMedID:19209902ReactivityRatApplications:WesternBlot

Immunohistochemistry

Canhypoxiaenhancesexualarousal?-Molecular-biologicalanalysisofthehypothalamusinmaleratsplacedwithoestrousfemaleratsunderhypoxicconditions.

Inoue,H.,Yoshida,M.Nishio,H.andTatsumi,S.(2016)IntJClinExpMed.9(10):19512-19520

PubMedID:N/AReactivityRatApplications:Immunohistochemistry

DetectionofconstitutiveandinducibleHSP70proteinsinformalinfixedhumanbraintissue.

Preusse-Prange,A.,Modrow,J.H.,Schwark,T.,vonWurmb-Schwark,N.(2014)ForensicSciInt.235:62-7.

PubMedID:24447452ReactivityHumanApplications:Immunohistochemistry

Co-overexpressionofBag-1andheatshockprotein70inhumanepidermalsquamouscellcarcinoma:Bag-1-mediatedresistanceto5-fluorouracilinducedapoptosis.

Wood,J.etal.(2011)BrJCancer.104(9):1459-1471.

PubMedID:21522149ReactivityHumanApplications:Immunohistochemistry

FlowCytometry

HeatShockEnhancestheExpressionoftheHumanTCellLeukemiaVirusType-I(HTLV-I)Trans-Activator(Tax)AntigeninHumanHTLV-IInfectedPrimaryandCulturedTCells.

Kunihiro,M.etal.(2016)Viruses.8(7).

PubMedID:27409630ReactivityHumanApplications:FlowCytometry

ProstaglandinESynthaseInteractswithInducibleHeatShockProtein70AfterHeatStressinBovinePrimaryDermalFibroblastCells.

Richter,C.,Viergutz,T.,Schwerin,M.andWeitzel,J.M.(2014)CytometryA.87(1):61-7.

PubMedID:25412999ReactivityBovineApplications:FlowCytometry

Immunocytochemistry/Immunofluorescence

Heatshockprotein70regulatesdegradationofthemumpsvirusphosphoproteinviatheubiquitin-proteasomepathway.

Katoh,H.etal.(2014)JVirol.89(6):3188-99.

PubMedID:25552722ReactivityHumanApplications:Immunocytochemistry/Immunofluorescence

OtherCitations

ProstaglandinESynthaseInteractswithInducibleHeatShockProtein70AfterHeatStressinBovinePrimaryDermalFibroblastCells.

Richter,C.,Viergutz,T.,Schwerin,M.andWeitzel,J.M.(2014)CytometryA.87(1):61-7.

PubMedID:25412999ReactivityBovineApplications:Immunoprecipitation

FastingEnhancesTRAIL-MediatedLiverNaturalKillerCellActivityviaHSP70Upregulation.

Dang,V.T.A.etal.(2014)PLoSOne.9(10):e110748.

PubMedID:25356750ReactivityMouseApplications:ProteinInhibition

MacrophageinflammatoryproteinderivativeECI301enhancesthealarmin-associatedabscopalbenefitsoftumorradiotherapy.

Kanegassaki,S.,Matsushima,K.,Shiraishi,K.,Nakagawa,K.andTsuchiya,T.(2014)CancerRes.74(18):5070-8.

PubMedID:25038226ReactivityMouseApplications:Immunoprecipitation

BioMarkerAnalysiswithGratingCoupledSurfacePlasmonCoupledFluorescence.

Mendoza,A.,Dias,J.A.,Zeltner,T.andLawrence,D.A.(2014)JAdvBio&Biotech.1(1):1-22.

PubMedID:N/AReactivityHumanApplications:AntibodyMicroarray

BiomarkerAnalysiswithGratingCoupledSurfacePlasmonCoupledFluorescence.

Mendoza,A.,Dias,J.A.,Zeltner,T.andLawrence,D.A.(2014)JAdvBio&Biotech.1(1):1-22.

PubMedID:N/AReactivityMouseApplications:AntibodyMicroarray

HeatShockProtein70PreventsbothTauAggregationandtheInhibitoryEffectsofPreexistingTauAggregatesonFastAxonalTransport.

Patterson,K.R.etal.(2011)Biochem.50(47):10300-10310.

PubMedID:22039833Reactivity<

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