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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/HSP65 Protein/SPR-116A/50-µg
商品详细StressMarq/HSP65 Protein/SPR-116A/50-µg
StressMarq/HSP65 Protein/SPR-116A/50-µg
StressMarq/HSP65 Protein/SPR-116A/50-µg
商品编号: SPR-116A
市场价: ¥4300.00
美元价: 2580.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameHSP65Protein
Description

MycobacteriumbovisBCGRecombinantHSP65PartialProtein

ApplicationsWB,SDS-PAGE,FunctionalAssay,ELISA
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesNotag

Properties

StorageBuffer20mMTris,150mMNaCl,10%glycerol
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationMulti-StepPurified
Specificity~65kDa
CiteThisProductMycobacteriumbovisBCGRecombinantHSP65Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-116)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDS-PAGEanalysis.

BIOLOGicalDescription

AlternativeNames60kDachaperonin2Protein,AntigenAProtein,CellwallproteinAProtein,groELProtein,GroEL2Protein,GroL2Protein,M.TuberculosiscellwallproteinAProtein,M.TuberculosisHSP65Protein,ProteinCpm602Protein
ResearchAreasCancer,HeatShock
CellularLocalizationCytoplasm
AccessionNumberAAQ64501.1
SwissProtQ1EHB9
ScientificBackgroundHSP65isolatedfromMycobacteriumbovisBCG,isamemberoftheHSP60familyofheatshockproteins(2,3).HSP60saremitochondrialchaperoninsthataretypicallyheldresponsIBLeforthetransportationandrefoldingofproteinsfromthecytoplasmintothemitochondrialmatrix.Inadditiontoitsroleasaheatshockprotein,HSP60functionsasachaperonintoassistinfoldinglinearaminoacidchainsintotheirrespectivethree-dimensionalstructure.HSP60sareaubiquitousclassofHSPsthatspecificallypromotethefoldingandassemblyofcellularpolypeptidesinanATP-dependentmanner(1).Specifically,sequencecomparisonofHSP65fromdifferentmycobacteriumstrainsshowedthattheproteinsequenceofM.bovisBCGisidenticaltothatofM.tuberculosis,andverysimilartothatofM.leprae,thepathogensthatcausetuberculosisandtuberculoidleprosy,respectively(2,4).MycobacteriumbovisBCGHSP65wasidentifiedastheimmunodominantantigenduringmycobacterialdiseasesandvaccination.Itisalsobelievedtobetheantigenthatinducesautoimmunedisease,suchasadjuvantarthritisinrats(5,6).
References1.KollH.,etal.(1992)Cell.68:1163-1175.
2.TholeJ.E.R.,etal.(1985)Infect.Immuno.50:800-806.
3.TholeJ.E.R.,etal.,(1987)Infect.Immuno.55:1466-1475.
4.ShinnickT.M.SweetserD.,TholeJ.,vanEmBDenJ.andYoungR.A.(1987)Infect.Immuno.55:1932-1935.
5.VanEdenW.,etal.(1988)Nature331:171-178.
6.CobelensP.M.,etal.(2002)Rheumatology41:775-779.

ProductImages

<p>SDS-PAGE of 65kDa M. Bovis Hsp65 protein (SPR-116).</p>

SDS-PAGEof65kDaM.BovisHsp65protein(SPR-116).

ProductCitations(6)

ELISA

PutativeconsequencesofexposuretoHelicobacterpyloriinfectioninpatientswithcoronaryheartdiseaseintermsofhumoralimmuneresponseandinflammation.

Matusiak,A.etal.(2016)ArchMedSci.12(1):45–54.

PubMedID:26925118Applications:ELISA

OtherCitations

IdentificationofmycobacterialRplJ/L10andRpsA/S1proteinsasnoveltargetsforCD4+Tcells.

Johnson,A.J.etal.(2017)InfectImmun.85(4).pii:e01023-16.

PubMedID:28115505Applications:ProteinBindingAssay

LckInhibitsHeatShockProtein65-MediatedReverseCholesterolTransportinTCells.

Luo,T.etal.(2016)JImmunol.197(10):3861-3870.

PubMedID:27742830Applications:FunctionalAssay

Heatshockproteinexpressionaffectshigh-densitylipoproteinfunctioninatherosclerosis.

Tang,Y.,Luo,Y.andWu,Q.(2016)IntJClinExpPathol.9(4):4158-4166

PubMedID:17920518Applications:FunctionalAssay

Heatshockprotein65promotesatherosclerosisthroughimpairingthepropertiesofhighdensitylipoprotein.

Sun,H.etal.(2014)Atherosclerosis.237(2):853-61

PubMedID:25463133Applications:FunctionalAssay

Detectionofautoantibodiesagainstheatshockproteinsandcollapsinresponsemediatorproteinsinautoimmuneretinopathy.

Adamus,G.et.al.(2013)BMCOphthalmol.0.575

PubMedID:24066722Applications:WesternBlotControl

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。