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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/HSP27 Protein/SPR-105A/50-µg
商品详细StressMarq/HSP27 Protein/SPR-105A/50-µg
StressMarq/HSP27 Protein/SPR-105A/50-µg
StressMarq/HSP27 Protein/SPR-105A/50-µg
商品编号: SPR-105A
市场价: ¥2460.00
美元价: 1476.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameHSP27Protein
Description

HumanRecombinantHSP27Protein

ApplicationsWB,SDS-PAGE,FunctionalAssay,ELISA
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesHistag

Properties

StorageBuffer50mMTris/HCl,pH8,0.3MNaCl
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
Specificity~27kDa
CiteThisProductHumanRecombinantHSP27Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-105)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDS-PAGEanalysis.

BIOLOGicalDescription

AlternativeNames28kDaheatshockProtein,CMT2FProtein,HSP25Protein,HSP27Protein,HSP28Protein,HSPB1Protein,SRP27Protein
ResearchAreasCancer,HeatShock
CellularLocalizationCytoplasm,Nucleus
AccessionNumberBC012768
GeneID3315
SwissProtP04792
ScientificBackgroundHSP27sbelongtoanabundantandubiquitousfamilyofsmallheatshockproteins(sHSP).ItisanimportantHSPfoundinbothnormalhumancellsandcancercells.ThebasicstructureofmostsHSPsisahomologousandhighlyconservedaminoacidsequence,withanα-crystallin-domainattheC-terminusandtheWD/EPFdomainatthelessconservedN-terminus.ThisN-terminusisessentialforthedevelopmentofhighmolecularoligomers(1,2).HSP27-oligomersconsistofstabledimersformedbyasmanyas8-40HSP27proteinmonomers(3).Theoligomerizationstatusisconnectedwiththechaperoneactivity:aggregatesoflargeoligomershavehighchaperoneactivity,whereasdimershavenochaperoneactivity(4).HSP27islocalizedtothecytoplasmofunstressedcellsbutcanredistributetothenucleusinresponsetostress,whereitmayfunctiontostABIlizeDNAand/orthenuclearmembrane.Otherfunctionsincludechaperoneactivity(asmentionedabove),Thermotoleranceinvivo,inhibitionofapoptosis,andsignaltransduction.Specifically,invitro,itactsasanATP-independentchaperonebyinhibitingproteinaggregationandbystabilizingpartiallydenaturedproteins,whichensuresrefoldingoftheHSP70complex.HSP27isalsoinvolvedintheapoptoticsignalingpathwaybecauseitinterfereswiththeactivationofcytochromec/Apaf-1/dATPcomplex,therebyinhibitingtheactivationofprocaspase-9.ItisalsohypothesizedthatHSP27mayservesomeroleincross-bridgeformationbetweenactinandmyosin(5).Andfinally,HSP27isalsothoughttobeinvolvedintheprocessofcelldifferentiation.Theup-regulationofHSP27correlateswiththerateofphosphorylationandwithanincreaseoflargeoligomers.ItispossIBLethatHSP27mayplayacrucialroleinterminationofgrowth(6).LookingformoreinformationonHSP27?VisitournewHSP27ScientificResourceGuideathttp://www.HSP27.com.
References1.KimK.K.,KimR.,andKim,S.(1998)Nature394(6693):595-599.
2.VanMontfortR.,SlingsbyC.,andVierlingE.(2001)AddvProteinChem.59:105-56.
3.EhrnspergerM.,GraberS.,GaestelM.andBuchnerJ.(1997)EMBOJ.16:221-229.
4.CioccaD.R.,OesterreichS.,ChamnessG.C.,McGuireW.L.,andFuguaS.A.(1993)JNatlCancerInst.85(19):1558-70.
5.SartoC.BinnzP.A.andMocarelliP.(2000)Electrophoresis.21(6):1218-26.
6.ArrigoA.P.(2005)JCellBiochem.94(2):241-6.

ProductImages

<p>SDS-PAGE of 28kDa Hsp27 protein (SPR-105).</p>

SDS-PAGEof28kDaHsp27protein(SPR-105).

ProductCitations(2)

OtherCitations

Re-examiningHSPC1inhibitors.

Lee,S.L.etal.(2017)CellStressChaperones.22(2):293-306.

PubMedID:28255900Applications:WesternBlotControl

ModulationofAmyloid-βProteinPrecursorExpressionbyHspB1.

Conway,M.,Nafar,F.,Straka,T.,Mearow,K.(2014)JAlzheimersDis.42(2):435-50.

PubMedID:24898650

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。