StressMarq/Anti-HSC70 (plant) Antibody/SPC-302D/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-HSC70 (plant) Antibody/SPC-302D/100-µl

StressMarq/Anti-HSC70 (plant) Antibody/SPC-302D/100-µl

商品编号： SPC-302D

品牌： StressMarq Biosciences

市场价： ¥6160.00

美元价： 3696.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName HSC70(plant)Antibody

Description

RabbitAnti-PlantHSC70(plant)Polyclonal

SpeciesReactivity Pea(Pisumsativum),Plant,Wheat(Triticumspp.)

Applications WB,ELISA,IP

AntibodyDilution WB(1:50000);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Plant

Immunogen HSC70purifiedfromwheatgerm

Conjugates

Unconjugated

Properties

StorageBuffer	LyophilizedrabbitAntiserum.Forreconstitutionadd100µlofsterilewater.
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	Rabbitantiserum
Clonality	Polyclonal
Specificity	Detects~70kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-302,RRID:AB_1501424

BIOLOGicalDescription

AlternativeNames	HSP701Antibody,HSP702Antibody,HSP70.1Antibody,HSP72Antibody,HSPA1Antibody,HSPA1AAntibody,HSPA1BAntibody,HSPA8Antibody
ResearchAreas	Cancer,HeatShock
CellularLocalization	Cytoplasm,Melanosome
ScientificBackground	HSP70genesencodeabundantheat-inducible70-kDaHSPs(HSP70s).InmosteukaryotesHSP70genesexistaspartofamultigenefamily.Theyarefoundinmostcellularcompartmentsofeukaryotesincludingnuclei,mitochondria,chloroplasts,theendoplasmicreticulumandthecytosol,aswellasinbacteria.Thegenesshowahighdegreeofconservation,havingatleast5O%identity(1).TheN-terminaltwothirdsofHSP70saremoreconservedthantheC-terminalthird.HSP70bindsATPwithhighaffinityandpossessesaweakATPaseactivitywhichcanbestimulatedbybindingtounfoldedproteinsandsyntheticpeptides(2).WhenHSC70(constitutivelyexpressed)presentinmammaliancellswastruncated,ATPbindingactivitywasfoundtoresideinanN-terminalfragmentof44kDawhichlackedpeptidebindingcapacity.PolypeptidebindingabilitythereforeresidedwithintheC-terminalhalf(3).ThestructureofthisATPbindingdomaindisplaysmultiplefeaturesofnucleotidebindingproteins(4).Whencellsaresubjectedtometabolicstress(e.g.,heatshock)amemberoftheHSP70family,HSP70(HSP72),isexpressed;HSP70ishighlyrelatedtoHSC70(>90%sequenceidentity).ConstitutivelyexpressedHSC70rapidlyformsastablecomplexwiththehighlyinducIBLeHSP70incellsfollowingheatshock.TheinteractionofHSC70withHSP70isregulatedbyATP.Thesetwoheatshockproteinsmovetogetherinthecellexperiencingstress.FurThermore,researchonHSC70hasimplicatesitwitharoleinfacilitatingtherecoveryofcentrosomalstructureandfunctionafterheatshock(5).
References	1.BoorsteinW.R.,ZiegelhofferT.,andCraigE.A.(1993)J.Mol.Evol.38(1):1-17. 2.RothmanJ.(1989)Cell59:591-601. 3.DeLuca-Flahertyetal.(1990)Cell62:875-887. 4.BorkP.,SanderC.,andValenciaA.(1992)Proc.NatlAcad.Sci.USA89:7290-7294. 5.BrownC.L.etal.(1996)J.Biol.Chem.271(2):833-840.

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品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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