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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/HOP蛋白质/SPR-302C/2x100-微克
商品详细StressMarq/HOP蛋白质/SPR-302C/2x100-微克
StressMarq/HOP蛋白质/SPR-302C/2x100-微克
StressMarq/HOP蛋白质/SPR-302C/2x100-微克
商品编号： SPR-302C
市场价： ¥8140.00
美元价： 4884.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name HOP Protein
Description

Human Recombinant HOP Protein

Applications WB, SDS-PAGE, Functional Assay
Concentration Lot/batch specific. See included datasheet.
Conjugates His tag

Properties

Storage Buffer 20mM HEPES buffer pH7.2, 80mM NaCl, 10% glycerol
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Specificity ~63 kDa
Cite This Product Human Recombinant HOP Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-302)
Certificate of Analysis This product has been certified >90% pure using SDS PAGE analysis. 4uM SPR-302, when added to 2uM SPR-300 (Aha1)-activated HSP90 (2uM; His-tagged HSP90 beta) in 33mM Hepes pH7.2, 30mM NaCl, 5mM MgCl2, 1mM DTT, 1.5mM ATP in a 100ul reaction at 37 degrees C, eliminated all Aha1-mediated ATPase stimulation as well as intrinsic HSP90 ATPase activity. (This is an enzyme-linked ATP regeneration assay tracking loss of NADH absorbance at 340nm).

Biological Description

Alternative Names HSP co chaperone Protein
Research Areas Cancer, Heat Shock
Cellular Localization Cytoplasm, Nucleus
Accession Number NP_006810.1
Gene ID 10963
Swiss Prot P31948
Scientific Background Hop (HSP70/HSP90 Organizing Protein), or Stress-induced Phosphoprotein 1 (STI1) as it is also known, is a 60kDa protein that belongs to the large group of co-chaperones which regulate and assist the major chaperones. It is located in diverse cellular regions and can move between the cytoplasm and the nucleus. It functions to reversibly link together the protein chaperones HSP70 and HSP90. HOP contains three tetratricopeptide repeat (TPR) domains, TPR1, TPR2a and TPR2b. HSP70 binding has been localized to TRP1 and sp90 binding have been localized to TPR2a (1). It has also been found to modulate the chaperone activities of the linked proteins and possible interacts with other chaperones and proteins. It has also been found to participate in other complexes besides the HSP70/HSP90 one (2). HOP is closely related to human 63kDa protein that is sensitive to simian virus SV40 transformation, and is related to the yeast heat-shock- responsive STI1 gene product (3, 4).
References 1. Flom G., Behal R.H., Rosen L., Cole D.G., Johnson J.L. (2007) Biochem J. 404(1): 159-167.
2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt3): 789-796.
3. Honore B.H., et al. (1992) J Biol Chem. 267: 8485-8491.
4. Nicolet C.M., et al. (1989) Mol Cell Bio. 9: 3638-3646.

Product Images

<p>SDS-PAGE of his-tagged human HOP protein (SPR-302).</p>

SDS-PAGE of his-tagged human HOP protein (SPR-302).

Product Citations (3)

Other Citations

Hitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?

Koay, Y.C. et al. (2016) ChemMedChem. 11(8):881-92.

PubMed ID: 26805515 Applications: Protein Binding Assay

Dimerization of a heat shock protein 90 inhibitor enhances inhibitory activity.

Wahyudi, H., Wang, Y. and McAlpine, S. R. (2014) Org Biomol Chem. 12(5):765-73.

PubMed ID: 24323090 Applications: Protein Binding Assay

Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines.

Willmer, T., Contu, L., Blatch, G.L., and Edkins, A.L. (2013) Cancer Lett. 328 (2): 252-260.

PubMed ID: 23036489 Applications: Actin co-sedimentation assay

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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