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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/HO-1 Protein/SPR-315B/100-µg
商品详细StressMarq/HO-1 Protein/SPR-315B/100-µg
StressMarq/HO-1 Protein/SPR-315B/100-µg
StressMarq/HO-1 Protein/SPR-315B/100-µg
商品编号: SPR-315B
市场价: ¥7220.00
美元价: 4332.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameHO-1Protein
Description

RatRecombinantHO-1PartialProtein

ApplicationsWB,SDS-PAGE
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesHistag

Properties

StorageBuffer50mMTris/HClpH7.5,5mMBme,0.15NaCl,10%glycerol
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
Specificity~32kDa
CiteThisProductRatRecombinantHO-1Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-315)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDSPAGEanalysis.

BIOLOGicalDescription

AlternativeNamesHemeoxygenase1Protein,HemoxProtein,HMOX1Protein,HO1Protein,HO1Protein,HSP32Protein
ResearchAreasCancer,OxidativeStress
CellularLocalizationEndoplasmicReticulum,Microsome
AccessionNumberNP_036712.1
GeneID24451
SwissProtP06762
ScientificBackgroundHeme-oxygenaseisaubiquitousenzymethatcatalyzestheinitialandrate-limitingstepsinhemecatabolismyieldingequimolaramountsofbiliverdin,ironandcarbonmonoxide.Biliverdinissubsequentlyconvertedtobilirubinandthefreeironissequesteredtoferritin(1).Theseproductshaveimportantphysiologicaleffectsascarbonmonoxideisapotentvasodilator;biliverdinandbilirubinarepotentantioxidants;andthefreeironincreasesoxidativestressandregulatestheexpressionofmanymRNAs(2).Therearethreeisoformsofheme-oxygenase,HO-1,HO-2andHO-3;howeverHO-1andHO-2arethemajorisoformsastheybothhavebeenidentifiedinmammals(3).HO-1,alsoknownasheatshockprotein32,isaninducIBLeisoformactivatedbymostoxidativestressinducers,cytokines,inflammatoryagentsandheatshock.HO-2isaconstitutiveisoformwhichisexpressedunderhomeostaticconditions.HO-1isalsoconsideredtobeacytoprotectivefactorinthatfreehemeishighlyreactiveandcytotoxic,andsecondly,carbonmonoxideisamediatorinhibitingtheinflammatoryprocessandbilirubinisascavengerforreactiveoxygen,bothofwhicharetheendproductsofhemecatalyzation(4).IthasalsobeenshownthatHO-1deficiencymaycausereducedstressdefense,apro-inflammatorytendency(5),susceptibilitytoatheroscleroticlesionformation(6),endothelialcellinjury,andgrowthretardation(7).Up-regulationofHO-1isthereforesaidtobeoneofthemajordefensemechanismsofoxidativestress(4).
References1.FrohM.etal.(2007)WorldJ.Gastroentereol13(25):3478-86.
2.ElbirtK.K.andBonkovskyH.L.(1999)ProcAssocAmPhysicians111(5):348-47.
3.MainesM.D.,TrakshelG.M.,andKuttyR.K.(1986)JBiolChem261:411–419.
4.BrydunA.,etal.(2007)HypertensRes30(4):341-8.
5.PossK.D.andTonegawaS.(1997).ProcNatlAcadSciUSA.94:10925–10930.
6.YetS.F.,etal.(2003)FASEBJ.17:1759–1761.
7.YachieA.,etal.(1999)JClinInvest.103:129–135.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。