StressMarq/Anti-HEF1 Antibody (pTyr166)/SPC-933D-APC/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-HEF1 Antibody (pTyr166)/SPC-933D-APC/100-µl

StressMarq/Anti-HEF1 Antibody (pTyr166)/SPC-933D-APC/100-µl

商品编号： SPC-933D-APC

品牌： StressMarq Biosciences

市场价： ¥6820.00

美元价： 4092.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName HEF1Antibody(pTyr166)

Description

RabbitAnti-HumanHEF1(pTyr166)Polyclonal

SpeciesReactivity Human

Applications WB,AM

AntibodyDilution WB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen Aphospho-specificpeptidecorrespondingtoresiduessurroundingTyr166ofhumanHEF1(AA163-169)

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	PeptideAffinityPurified
Clonality	Polyclonal
Specificity	Detects92.861kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-933,RRID:AB_2707193
CertificateofAnalysis	A1:250dilutionofSPC-933wassufficientfordetectionofHEF1(pTyr166)in10µgofhumanbreastcancercell(MCF7)lysatesbyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	CaslikedockingAntibody,Casscaffoldingproteinfamilymember2Antibody,CAS-LAntibody,CAS2Antibody,CrkassociatedsubstraterelatedAntibody,Enhanceroffilamentation1Antibody,Enhanceroffilamentation1p55Antibody,NEDD-9Antibody,Neuralprecursorcellexpresseddevelopmentallydown-regulatedprotein9Antibody,P105Antibody,RenalcarcinomaantigenNY-REN-12Antibody
ResearchAreas	Cancer,Apoptosis,CellSignaling,EpigeneticsandNuclearSignaling,FAK/PYK,ProteinPhosphorylation,Transcription,TyrosineKinases
CellularLocalization	Cytoplasm,CellCortex,Cytoskeleton,Golgiapparatus
AccessionNumber	NP_001135865
GeneID	4739
SwissProt	Q14511
ScientificBackground	HEF1,alsoknownasEnhanceroffilamentation1,CRKassociatedsubstrate-relatedprotein,CAS-L,CasL,p105andNeuralprecursorcellexpresseddevelopmentallydown-regulated9istheproductoftheNEDD9(CASGL)gene.HEF1functionsasadockingproteinthatplaysacentralcoordinatingrolefortyrosine-kinase-basedsignalingrelatedtocelladhesion.HEF1mayalsofunctionintransmittinggrowthcontrolsignalsbetweenfocaladhesionsatthecellperipheryandthemitoticspindleinresponsetoadhesionorgrowthfactorsignalsinitiatingcellproliferation.HEF1mayalsoplayanimportantroleinintegrinbeta-1orBcellantigenreceptor(BCR)mediatedsignalinginB-andT-cells.Integrinbeta-1stimulationleadstorecruitmentofvariousproteinsincludingCRK,NCKandSHPTP2tothetyrosinephosphorylatedform.HEF1formsahomodimerandcanheterodimerizewithHLHproteinsID2,E12,E47andalsowithp130cas.HEF1alsoformscomplexesinvivowithrelatedadhesionfocaltyrosinekinase(RAFTK),adapterproteinCRKLandLYNkinaseandalsointeractswithMICALandTXNL4/DIM1.Thisproteinlocalizestoboththecellnucleusandthecellperipheryandisdifferentlylocalizedinfibroblastsandepithelialcells.Infibroblasts,itispredominantlynuclearandinsomecellsispresentintheGolgiapparatus.Inepithelialcells,itislocalizedpredominantlyinthecellperipherywithparticularconcentrationinlamellipodia,butitisalsofoundinthenucleus.HEF1iswidelyexpressedalthoughhigherlevelsaredetectedinkidney,lung,andplacentaltissue.HEF1isalsodetectedinT-cells,B-cellsanddiversecelllines.HEF1isactivateduponinductionofcellgrowth.Cellcycle-regulatedprocessingproducesfourisoforms:p115,p105,p65,andp55.Isoformp115arisesfromp105phosphorylationandappearslaterinthecellcycle.Isoformp55arisesfromp105asaresultofcleavageatacaspasecleavage-relatedsiteanditappearsspecificallyatmitosis.Thep65isoformispoorlydetected.Isoformsp105andp115arepredominantlycytoplasmicandassociatewithfocaladhesionswhilep55associateswiththemitoticspindle.

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APC(Allophycocyanin)

Overview:

Highquantumyield
Largephycobiliprotein
6chromophorespermolecule
Isolatedfromredalgae
MolecularWeight:105kDa

APCDatasheet

APC Fluorophore Absorption and Emission Spectrum

OpticalProperties:

λ_ex =650nm

λ_em=660nm

ε_max=7.0×10⁵

Φ_f= 0.68

Brightness= 476

Laser =594or633 nm

Filterset =Cy®5

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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