StressMarq/GW5074/SIH-451-5MG/5-mg
商品编号：
SIH-451-5MG
市场价：
¥1980.00
美元价：
1188.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | GW5074 |
| Description | c-Raf1kinaseinhibitor |
| Purity | >98%(TLC) |
| CASNo. | 220904-83-6 |
| MolecularFormula | C15H8Br2INO2 |
| MolecularWeight | 520.9 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleto1mMinethanolandto100mMinDMSO |
| Source | Synthetic |
| Appearance | Yellowtoorangesolid |
| SMILES | C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2 |
| InChI | InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3- |
| InChIKey | LMXYVLFTZRPNRV-KMKOMSMNSA-N |
| SafetyPhrases | Classification:Notahazardoussubstanceormixture.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
| CiteThisProduct | GW5074(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-451) |
BIOLOGicalDescription
| AlternativeNames | 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 5924208 |
| ScientificBackground | GW5074isapotentandselectivec-Raf1kinaseinhibitor.GW5074shows≥100-foldselectivityforrafkinaseoverCDK1,CDK2,c-src,ERK2,MEK,p38,Tie2,VEGFR2andc-fm.≥100-foldselectivityforrafkinaseoverCDK1,CDK2,c-src,ERK2,MEK,p38,Tie2,VEGFR2andc-fm.GW5074hasbeenshowntoblocklowpotassiuminducedcelldeath,aswellas,preventneurodegeneration.GW5074iscell-permeable. |
| References | 1.ChinP.C.,etal.(2004)J.NeuRochem.90(3):595–608. 2.LackeyK.,etal.(2000).BioorganicMed.Chem.Ltr.10(3):223–226. 3.ChangM.S.,(2005).CellSignal.17(3):299–310. |
ProductImages
ChemicalstructureofGW5074(SIH-451),ac-Raf1kinaseinhibitor.CAS#:220904-83-6.MolecularFormula:C15H8Br2INO2.MolecularWeight:520.9g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
