StressMarq/GW2580/SIH-449-5MG/5-mg
商品编号：
SIH-449-5MG
市场价：
¥1340.00
美元价：
804.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | GW2580 |
| Description | cFMSkinaseinhibitor |
| Purity | >98%(HPLC) |
| CASNo. | 870483-87-7 |
| MolecularFormula | C20H22N4O3 |
| MolecularWeight | 366.4 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO:10mg/ml,clear(warmed) |
| Source | Synthetic |
| Appearance | Whitetobeigesolid |
| SMILES | COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC |
| InChI | InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h4-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) |
| InChIKey | MYQAUKPBNJWPIE-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Acutetoxicity,Oral(Category4),H302Skinirritation(Category2),H315Eyeirritation(Category2A),H319Specifictargetorgantoxicity-singleexposure(Category3),Respiratorysystem,H335SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H302Harmfulifswallowed.H315Causesskinirritation.H319Causesseriouseyeirritation.H335Maycauserespiratoryirritation.Precautionarystatements:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P271Useonlyoutdoorsorinawell-ventilatedarea.P280Wearprotectivegloves/eyeprotection/faceprotection.P301+P312IFSWALLOWED:CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P302+P352IFONSKIN:Washwithplentyofsoapandwater.P304+P340IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P321Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P330Rinsemouth.P332+P313Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313Ifeyeirritationpersists:Getmedicaladvice/attention.P362Takeoffcontaminatedclothingandwashbeforereuse.P403+P233Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant. |
| CiteThisProduct | GW2580(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-449) |
BIOLOGicalDescription
| AlternativeNames | 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-Pyrimidinediamine,5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine,GW2580,GW-2580 |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 11617559 |
| ScientificBackground | GW2580isapotentandselective,ATP-competitiveinhibitorofcFMSkinase.Italsoinhibitsmacrophage-colonystimulatingfactorreceptor,M-CSF/CSF-1.cFMSisatypeIIIreceptortyrosinekinasethatbindstoM-CSForCSF-1.OverexpressionofCSF-1and/orFMShasbeenimplicatedinanumberofdiseasestates. |
| References | 1.ConwayJ.G.,etal.(2008)J.Pharm.Exp.Ther.326(1):41–50. 2.ConwayJ.G.,etal.(2005)Pro.Nat.Acad.Sci.USA.102(44):16078–16083. |
ProductImages
ChemicalstructureofGW2580(SIH-449),acFMSkinaseinhibitor.CAS#:870483-87-7.MolecularFormula:C20H22N4O3.MolecularWeight:366.4g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
