StressMarq/GF109203X/SIH-447-10MG/10-mg
商品编号：
SIH-447-10MG
市场价：
¥3400.00
美元价：
2040.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | GF109203X |
| Description | PKCkinaseinhibitor |
| Purity | >98%(TLC) |
| CASNo. | 133052-90-1 |
| MolecularFormula | C25H24N4O2 |
| MolecularWeight | 412.5 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleindimethylformamideorDMSO(10mg/ml,warmto40°Candvortexwell) |
| Source | Synthetic |
| Appearance | Redsolid |
| SMILES | C4=C(C3=C(C1=C[NH]C2=CC=CC=C12)C(=O)NC3=O)C5=C([N]4CCCN(C)C)C=CC=C5 |
| InChI | InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h4-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChIKey | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Acutetoxicity,Oral(Category4),H302Carcinogenicity(Category2),H351SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H302Harmfulifswallowed.H351SUSPectedofcausingcancer.Precautionarystatements:P201Obtainspecialinstructionsbeforeuse.P202Donothandleuntilallsafetyprecautionshavebeenreadandunderstood.P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P281Usepersonalprotectiveequipmentasrequired.P301+P312IFSWALLOWED:CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P308+P313IFexposedorconcerned:Getmedicaladvice/attention.P330Rinsemouth.P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant. |
| CiteThisProduct | GF109203X(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-447) |
BIOLOGicalDescription
| AlternativeNames | 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide,3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide,3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione,BisindolylmaleimideI |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 2396 |
| ScientificBackground | GF109203XisaverypotentinhibitorofproteinkinaseC;itisselectivefortheαandβ1isoforms;thiscouldleadtoanincreaseinautophagy.GF109203Xisalsoaninhibitorofglycogensynthasekinase-3(GSK-3)andhasanti-inflammatoryeffects.Ithasalsobeenseentoinhibittelomeraseactivityandnecrosis. |
| References | 1.ToullecD.,etal.(1991)J.Biol.Chem.266(24):15771–15781. 2.JacobsonP.B.,etal.(1995)J.Pharma.Exp.Ther.275(2):995–1002. 3.JiangQ.,etal.(2011)Mol.Biol.Cell.22(8):1167–1180. 4.KucheraS.,etal.(1993)AgentsandActions.39SpecNo:C169–173. |
ProductImages
ChemicalstructureofGF109203X(SIH-447),aPKCkinaseinhibitor.CAS#:133052-90-1.MolecularFormula:C25H24N4O2.MolecularWeight:412.5g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
