StressMarq/Geldanamycin- FITC/SIH-113A/1-mg
商品编号：
SIH-113A
市场价：
¥4020.00
美元价：
2412.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Geldanamycin-FITC |
| Description | Hsp90inhibitor |
| Purity | >98% |
| CASNo. | 30562-34-6 |
| MolecularFormula | C55H63N5O13S |
| MolecularWeight | 560.6 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO |
| Source | Synthetic |
| Appearance | PurpleSolid |
| SMILES | C[[email protected]]1C[[email protected]@H]([[email protected]@H]([[email protected]](/C=C(/[[email protected]@H]([[email protected]](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)C)C)O)OC |
| InChI | InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35) |
| InChIKey | QTQAWLPCGQOSGP-KSRBKZBZSA-N |
| SafetyPhrases | Classification:Harmful.Maybeharmfulifinhaled,swallowedorabsorbedthroughskin.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionRiskPhrases:R68-PossIBLeriskofirreversibleeffects |
| CiteThisProduct | Geldanamycin-FITC(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-113) |
BIOLOGicalDescription
| AlternativeNames | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azABIcyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate |
| ResearchAreas | Cancer,HeatShock |
| PubChemID | 5288382 |
| ScientificBackground | GeldanamycinisabenzoquinoidansamycinproducedbyStreptomyceshygroscopicus.ItbindsspecificallytoheatshockproteinHSP90anddownregulatestargetproteinsincludingtyrosinekinases,steroidreceptors,transcriptionfactorsandcellcycleregulatorykinases(1,2).Itinducestheinactivation,destabilizationandeventualdegradationofHIF-1α(3).Itisalsoaninhibitorofpp60srctyrosinekinaseandofc-mycgeneexpressioninmurinelymphoblastomacells.Itinhibitsthetransformingactivityofabl,erbB,fps,src,andyes(4).Geldanamyciniscapableofdestabilizingseveraloncogeneandproto-oncogeneproducts;itisapotentinhibitorofthenuclearhormonereceptorfamily(5).Itprotectsagainstα-synucleintoxicitytodopaminergicneuronsinDrosophila,anddestabilizesmutantp53proteinfromanumberofbreast,leukemic,andprostatecelllines(6).Inhibitsbasalandhypoxia-inducedexpressionofc-Jun(IC50=75nM)andabolisheshypoxia-inducedincreaseinc-JunN-terminalkinase(JNK)activity.InhibitstelomeraseactivitythroughinhibitionofHSP90,achaperonerequiredfortheassemblyandactivationoftelomeraseinhumancells(6).Itis~10-foldmorepotentthanherbimycinA.LookingformoreinformationonHSP90?VisitournewHSP90ScientificResourceGuideathttp://www.HSP90.ca. |
| References | 1.WhitesellL.,etal.(1994)Proc.Natl.Acad.Sci.USA91:8324. 2.NeckersL.(2002)TrendsMol.Med.8:S55. 3.MabjeeshN.J.,etal.(2002)CancerRes.62:2478. 4.ChavanyC.,etal.1996)Amer.SocietyBiochemMolBio.9:4974-4977. 5.VillaR.,etal.(2003)Carcinogenesis.24(5):851-9. 6.YamakiH.,Iguchi-ArigaS.M.,andArigaH.(1989)JAntibiot(Tokyo).42(4):604-10. |
ProductImages
ChemicalstructureofGeldanamycin-FITC(SIH-113),aHsp90inhibitor.CAS#:30562-34-6.MolecularFormula:C55H63N5O13S.MolecularWeight:560.6g/mol.
ProductCitations(2)
FlowCytometry
OtherCitations
FragmentScreeningUsingCapillaryElectrophoresis(CEfrag)forHitIdentificationofHeatShockProtein90ATPaseInhibitors.
Austin,C.etal.(2012)JBiomolScreen.17(7):868-76.
PubMedID:22573733Applications:FluorescencePolarizationAssay
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
