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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/FK506/SIH-214-50MG/50-mg
商品详细StressMarq/FK506/SIH-214-50MG/50-mg
StressMarq/FK506/SIH-214-50MG/50-mg
StressMarq/FK506/SIH-214-50MG/50-mg
商品编号: SIH-214-50MG
市场价: ¥4200.00
美元价: 2520.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameFK506
Description

FKBPinhibitor

Purity>98%
CASNo.109581-93-3
MolecularFormulaC44H69NO12·H2O
MolecularWeight804.02

Properties

StorageTemperature-20ºC
ShippingTemperatureShippedAmbient
ProductTypeInhibitor
SolubilitySolubleto100mMinethanol,andto100mMinDMSO
SourceSynthetic
AppearanceWhiteSolid
SMILESCCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
InChIInChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)4
InChIKeyQJJXYPPXXYFBGM-LFZNUXCKSA-N
SafetyPhrasesClassification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionHazardPhrases:H301PrecautionaryPhrases:P301+P310
CiteThisProductFK506(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-214)

BIOLOGicalDescription

AlternativeNames3-(3-Pyridinyl)propyl1-(3,3-dimethyl-2-oxopentanoyl)prolinate,Tacrolimus,Fujimycin
ResearchAreasCancer,Apoptosis
PubChemID445643
ScientificBackgroundFK506orFujimycinorTacrolimus,isanimmunosuppressant.Itismainlyusedafterallogeneicorgantransplants,butcanalsobeusedtopicallyinthetreatmentofeczema,uveitisandvitiligo(1).ItisamacrolidethatpreventsthedephosphorylationofNF-AT.Itreducespeptidyl-prolylisomeraseactivitybybindingtoFKBP12creatinganewcomplexthatinteractswithandinhibitscalcineurin(2,3).
References1.NanetteB.,etal.(2004)JAmAcadDerm.51(5):760-766.
2.GanongW.F.,ReviewofMedicalPhysiology(22nded.)LangeMedicalBooks.P.530
3.LiuJ.LaneW.,FriedmanJ,WeissmanIandSchreiberS.(1991)Cell.66(4):807-815

ProductImages

<p>Chemical structure of FK506 (SIH-214), a FKBP inhibitor. CAS #: 109581-93-3. Molecular Formula: C44H69NO12 · H2O. Molecular Weight: 804.02 g/mol.</p>

ChemicalstructureofFK506(SIH-214),aFKBPinhibitor.CAS#:109581-93-3.MolecularFormula:C44H69NO12·H2O.MolecularWeight:804.02g/mol.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。