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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-FAK Antibody (pTyr577)/SPC-978D-A488/100-µl
商品详细StressMarq/Anti-FAK Antibody (pTyr577)/SPC-978D-A488/100-µl
StressMarq/Anti-FAK Antibody (pTyr577)/SPC-978D-A488/100-µl
StressMarq/Anti-FAK Antibody (pTyr577)/SPC-978D-A488/100-µl
商品编号: SPC-978D-A488
市场价: ¥6840.00
美元价: 4104.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameFAKAntibody(pTyr577)
Description

RabbitAnti-HumanFAK(pTyr577)Polyclonal

SpeciesReactivityHuman
ApplicationsWB,AM
AntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenAphospho-specificpeptidecorrespondingtoresiduessurroundingTyr577ofhumanFAK(AA574-580)
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationPeptideAffinityPurified
ClonalityPolyclonal
SpecificityDetects119.233kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-978,RRID:AB_2708003
CertificateofAnalysisA1:250dilutionofSPC-978wassufficientfordetectionofFAK(pTyr577)in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesFADK1Antibody,FADKAntibody,FAKrelatednonkinasepolypeptideAntibody,FAK1Antibody,FAKAntibody,Focaladhesionkinase1Antibody,FocaladhesionkinaseisoformFAKDel33Antibody,FocaladhesionkinaserelatednonkinaseAntibody,FRNKAntibody,p125FAKAntibody,PPP1R71Antibody,Proteinphosphatase1regulatorysubunit71Antibody,Proteintyrosinekinase2Antibody,Ptk2Antibody,PTK2proteintyrosinekinase2Antibody
CellularLocalizationCellJunctions,Cellmembrane,FocalAdhesion
AccessionNumberNP_722560
GeneID5747
SwissProtQ05397
ScientificBackgroundFAK,alsoknownasPTK2,isanon-receptorprotein-tyrosinekinasethatisactivatedbytyrosine-phosphorylationinresponsetointegrinclusteringinducedbycelladhesionorantibodycross-linking,orviaG-proteincoupledreceptor(GPCR)occupancybyligands.Itservesasadaptorprotein.ItislinkedtotheMAPKpathwayviaGrb2,andisalsolinkedtoPI3KandPLCgammapathways.ItplaysaroleasascaffoldforMDM2-mediatedp53degradation,andhasbeenimplicatedinregulationofcell-cellcontacts,microtubulestABIlityandcontrolofgenetranscription.FAKhashighexpressionlevelsinvarioushumancancersasitpromotestumourcellmotility,matrixdegradation,angiogenesisandsuppressesapoptosis,anoikisandsenescence.

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 ATTO488
Overview:
  • Highfluorescenceyield
  • Highphotostability
  • Veryhydrophilic
  • Excellentsolubilityinwater
  • Verylittleaggregation
  • Newdyewithnetchargeof-1
  • MolarMass:804g/mol 

ATTO488Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOpticalProperties:

λex =501nm

λem=523nm

εmax=9.0×104

Φf= 0.80

τfl =4.1ns

Brightness= 72

Laser = 488 nm

Filterset = FITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。