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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-ERK2 Antibody/SPC-1143D-A390/100-µl
商品详细StressMarq/Anti-ERK2 Antibody/SPC-1143D-A390/100-µl
StressMarq/Anti-ERK2 Antibody/SPC-1143D-A390/100-µl
StressMarq/Anti-ERK2 Antibody/SPC-1143D-A390/100-µl
商品编号: SPC-1143D-A390
市场价: ¥6860.00
美元价: 4116.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

Product Name ERK2 Antibody
Description

Rabbit Anti-Human ERK2 Polyclonal

Species Reactivity Human, Mouse
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Synthetic peptide of human ERK2 (AA269-283)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 42 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-1143, RRID: AB_2710973
Certificate of Analysis A 1:250 dilution of SPC-1143 was sufficient for detection of ERK2 in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names ERK Antibody, ERT1 Antibody, ERK2 Antibody, Extracellular Signal Regulated Kinase 2 Antibody, MAP kinase 1 Antibody, MAP kinase 2 Antibody, MAP kinase isoform p42 Antibody, MAPK1 Antibody, MAPK2 Antibody, Mitogen-activated protein kinase 1 Antibody, Mitogen-activated protein kinase 2 Antibody, MK01_HUMAN Antibody, P38 Antibody, P40 Antibody, P41 Antibody, P42MAPK Antibody, PRKM1 Antibody, PRKM2 Antibody protein kinase, protein tyrosine kinase ERK2 Antibody
Cellular Localization Cytoplasm, Cytoskeleton, Nucleus, Spindle
Accession Number NP_620407
Gene ID 5594
Swiss Prot P28482
Scientific Background ERK2 or MAPK1 is a protein-serine/threonine kinase. Phosphorylates many diffrent transcription factors, such as ELK1. Acts as transcriptional repressor by binding directly to DNA. Essential for cyclin D1 induction. MAPK1 phosphoryltaes BCL2, which contributes to cell survival, the suppression of the apoptotic effect of BAD and up-regulation of the antiapoptotic protein MCL-1. Regulates accumulation of p53 during DNA damage response. Constitutively active in many human tumours, supposedly due to altered RAS, RAF, EGFR or other upstream elements. ERK/MAPK pathway was shown to promote cell motilty and tumour cell migration.

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  ATTO 390
Overview:

  • High fluorescence yield
  • Large Stokes-shift (89 nm)
  • Good photostability
  • Moderately hydrophilic
  • Good solubility in polar solvents
  • Coumarin derivate, uncharged
  • Low molar mass: 343.42 g/mol 

ATTO 390 Datasheet

ATTO 390 Fluorescent Dye Excitation and Emission SpectraOptical Properties:

λex = 390 nm

λem = 479 nm

εmax = 2.4×104

Φf = 0.90

τfl = 5.0 ns

Brightness = 21.6

Laser = 365 or 405 nm

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。