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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-ERK1 Antibody (pThr202 + pTyr204)/SPC-973D-A488/100-µl
商品详细StressMarq/Anti-ERK1 Antibody (pThr202 + pTyr204)/SPC-973D-A488/100-µl
StressMarq/Anti-ERK1 Antibody (pThr202 + pTyr204)/SPC-973D-A488/100-µl
StressMarq/Anti-ERK1 Antibody (pThr202 + pTyr204)/SPC-973D-A488/100-µl
商品编号： SPC-973D-A488
市场价： ¥6840.00
美元价： 4104.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name ERK1 Antibody (pThr202 + pTyr204)
Description

Rabbit Anti-Human ERK1 (pThr202 + pTyr204) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Thr202 and Tyr204 of human ERK1 (AA201-207)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 43.136 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-973, RRID: AB_2707913
Certificate of Analysis A 1:250 dilution of SPC-973 was sufficient for detection of ERK1 (pThr202 + pTyr204) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names ERT2 Antibody, Extracellular Signal Regulated Kinase 1 Antibody, HGNC6877 Antibody, HS44KDAP Antibody, HUMKER1A Antibody, Insulin Stimulated MAP2 Kinase Antibody, MAP kinase 1 Antibody, MAP kinase 3 Antibody, MAP Kinase Antibody, MAP kinase isoform p44 Antibody, ERK1 Antibody, MAPK 1 Antibody, MAPK 3 Antibody, MAPK Antibody, MAPK1 Antibody, MGC20180 Antibody, Microtubule Associated Protein 2 Kinase Antibody, Mitogen Activated Protein Kinase 3 Antibody, MK03_HUMAN Antibody, OTTHUMP00000174538 Antibody, OTTHUMP00000174541 Antibody, p44 ERK1 Antibody, p44 MAPK Antibody, P44ERK1 Antibody, PRKM 3 Antibody, PRKM3 Antibody, Protein Kinase Mitogen Activated 3 Antibody
Cellular Localization Cytoplasm, Nucleus
Accession Number NP_002737
Gene ID 5595
Swiss Prot P27361
Scientific Background ERK1 or MAPK3 is ubiquitously expressed protein serine/threonine kinase involved in regulating cellular differentiation and proliferation in response to extracellular mitogens or growth factors. MAPK3 is activated by upstream signalling by monomeric G-proteins. MAPK3 activation leads to its translocation from the cytosol to the nucleus where it can target substrate proteins involved in cell cycle regulation; Cyclin D1, suppression of apoptosis; BCL2 and BAD, tumour supression; p53, cell migration; PAI-1, and MHCII mediated immune response; PPARg1. Dysfunction of MAPK3 expression and activity has been observed in a variety of cancers. Predominantly overexpression of MAPK3 or constitutive activation has been observed in cancer cell lines. Activation of MAPK3 does not appear to be due to mutations in the protein itself but rather aberrant signalling in upstream factors including Raf, Ras and epidermal growth factor receptor. MAPK3 may also have a role in promoting metastasis in invasive tumours.

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  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

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StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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