StressMarq/Epoxomicin/SIH-388-100UG/100-µg
商品编号：
SIH-388-100UG
市场价：
¥3900.00
美元价：
2340.00
产品分类：
上样缓冲液
公司分类：
DNA_buffer_solution
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Epoxomicin |
| Description | Proteasomeinhibitor |
| Purity | >95% |
| CASNo. | 134381-21-8 |
| MolecularFormula | C28H50N4O7 |
| MolecularWeight | 554.7 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(15mg/ml)ordichloromethane:methanol(9:1);insolubleinwater. |
| Source | Synthetic |
| Appearance | Whitesolid |
| SMILES | [[email protected]@H](CC)(C)[[email protected]@H](C(N[[email protected]](C(N[[email protected]@H]([[email protected]@H](C)O)C(=O)N[[email protected]](C(=O)NCC(=O)[[email protected]]1(C)OC1)CC(C)C)=O)[[email protected]](CC)C)=O)N(C)C |
| InChI | InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)/t16-,17 |
| InChIKey | DOGIDQKFVLKMLQ-JTHVHQAWSA-N |
| SafetyPhrases | Classification:Caution.Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-Avoidcontactwithskinandeyes |
| CiteThisProduct | Epoxomicin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-388) |
BIOLOGicalDescription
| AlternativeNames | N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide |
| ResearchAreas | CellSignaling |
| PubChemID | 11226684 |
| ScientificBackground | Epoxomicinisacellpermeable,potentandselectiveproteasomeinhibitororiginallyisolatedfromActinomycetesstrainbasedonitspotentinvivoantitumoractivity.Itisamorepotentinhibitorofthechymotrypsin-likeactivityoftheproteasomethanlactacystin.Epoxomicinalsoblockstrypsin-likeandPGPHactivitiesoftheproteasomeandregulatesantigenpresentationatnon-toxicdoses.IteffectivelyinhibitsNF-κBactivationinvitroandpotentlyblocksinflammationinvivointhemouseearedemaassay.Theubiquitin-proteasomesystem(UPS)andautophagyserveastwocomplementary,reciprocallyregulatedproteindegradationsystems,thusinhibitionofUPSbyEpoxomicinactivatesautophagy. |
| References | 1.F.Yang,etal.(2009)Neurosci.Lett.454:203. 2.K.Ohkawa,etal.(2004)Int.J.Oncol.24:425. 3.K.Schwarz,etal.(2000)J.Immunol.164:6147. 4.L.Meng,etal.(1999)PNAS.96:10403. 5.K.B.Kim,etal.(1999)Bioorg.Med.Chem.Lett.9:3335. 6.N.Sin,etal.(1999)Bioorg.Med.Chem.Lett.9:2283. 7.M.Hanada,etal.(1992)J.Antibiot.(Tokyo)45:1746. |
ProductImages
ChemicalstructureofEpoxomicin(SIH-388),aProteasomeinhibitor.CAS#:134381-21-8.MolecularFormula:C28H50N4O7.MolecularWeight:554.7g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
