StressMarq/Epothilone B/SIH-238-5MG/5-mg
商品编号：
SIH-238-5MG
市场价：
¥7000.00
美元价：
4200.00
产品分类：
上样缓冲液
公司分类：
DNA_buffer_solution
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | EpothiloneB |
| Description | MicrotubulestABIlizer |
| Purity | >98% |
| CASNo. | 152044-54-7 |
| MolecularFormula | C27H41NO6S |
| MolecularWeight | 507.68 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inducer |
| Solubility | Solubleto10mMinDMSO |
| Source | Synthetic |
| Appearance | WhiteSolid |
| SMILES | C[[email protected]]1CCC[[email protected]@]2([[email protected]@H](O2)C[[email protected]](OC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C |
| InChI | InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15) |
| InChIKey | QXRSDHAAWVKZLJ-PVYNADRNSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | EpothiloneB(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-238) |
BIOLOGicalDescription
| AlternativeNames | (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione,Patupilone |
| ResearchAreas | Cancer,Apoptosis |
| PubChemID | 448013 |
| ScientificBackground | Epothiloneareanewclassofcancerdrugs.Theypreventcancercellsfromdividingbyinterferingwithtubulin(1).EpithiloneBpossessthesamebiologicaleffectsaspaclitaxelinbothinvitroandculturedcells,becausetheysharethesamebindingsite(2).EpothilonehasalsobeenshowntoinducetubulinpolymerizationintomicrotubuleswithoutthepresenceofGTP.AnditalsocausescellcyclearrestattheG2-Mtransitionphase,leADIngtoeventualcellapoptosis(3). |
| References | 1.RosenbergS.,DevitaV.T.,HellmanS.(2005)Cancer:Principles&PracticeofOncology:LippincottWilliamsandWilkins. 2.JulienB.,ShahS.(2002)AntimicrobAgentsChemother.46(9):2772. 3.BalogD.M.,etal.(1996)AngewChem.108:2976. |
ProductImages
ChemicalstructureofEpothiloneB(SIH-238),aMicrotubulestabilizingagent.CAS#:152044-54-7.MolecularFormula:C27H41NO6S.MolecularWeight:507.68g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
