StressMarq/Anti-ENaC Gamma Antibody/SPC-405D-ALP/100-µg-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-ENaC Gamma Antibody/SPC-405D-ALP/100-µg

StressMarq/Anti-ENaC Gamma Antibody/SPC-405D-ALP/100-µg

商品编号： SPC-405D-ALP

品牌： StressMarq Biosciences

市场价： ¥6900.00

美元价： 4140.00

产地：美国(厂家直采)

公司：

产品分类：上样缓冲液

公司分类： DNA_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Overview:

Product Name ENaC Gamma Antibody

Description

Rabbit Anti-Rat ENaC Gamma Polyclonal

Species Reactivity Human, Mouse, Rat, African clawed frog (Xenopus laevis), Hamster

Applications WB, IHC, ICC/IF

Antibody Dilution WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

Host Species Rabbit

Immunogen Species Rat

Immunogen Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)

Concentration 1 mg/ml

Conjugates

Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

PerCP

Overview:

Peridinin-Chlorophyll-Protein Complex
Small phycobiliprotein
Isolated from red algae
Large stokes shift (195 nm)
Molecular Weight: 35 kDa

PerCP Datasheet

PerCP Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 482 nm

λ_em = 677 nm

ε_max = 1.96 x 10⁶

Laser = 488 nm

PE/ATTO 594

PE/ATTO 594 is a tandem conjugate, where PE is excited at 535 nm and transfers energy to ATTO 594 via FRET (fluorescence resonance energy transfer), which emits at 627 nm.

Overview:

High fluorescence yield
High photostability
Very hydrophilic
Excellent solubility in water
Very little aggregation

PE/ATTO 594 Datasheet

PE-ATTO 594 Fluorophore Conjugate Excitation and Emission Spectra

Optical Properties:

λ_ex = 535 nm

λ_em = 627 nm

Laser = 488 to 561 nm

FITC (Fluorescein)

Overview:

Excellent fluorescence quantum yield
High rate of photobleaching
Good solubility in water
Broad emission spectrum
pH dependent spectra
Molecular formula: C₂₀H₁₂O₅
Molar mass: 332.3 g/mol

FITC-Fluorescent-conjugate

FITC Fluorescein Fluorophore Excitation and Emission Spectra

Optical Properties:

λ_ex = 494 nm

λ_em = 520 nm

ε_max = 7.3×10⁴

Φ_f = 0.92

τ_fl = 5.0 ns

Brightness = 67.2

Laser = 488 nm

Filter set = FITC

ATTO 700

Overview:

High fluorescence yield
Excellent thermal and photostability
Quenched by electron donors
Very hydrophilic
Good solubility in polar solvents
Zwitterionic dye
Molar Mass: 575 g/mol

ATTO 700 Datasheet

ATTO 700 Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 700 nm

λ_em = 719 nm

ε_max = 1.25×10⁵

Φ_f = 0.25

τ_fl = 1.6 ns

Brightness = 31.3

Laser = 676 nm

Filter set = Cy®5.5

ATTO 680

Overview:

High fluorescence yield
Excellent thermal and photostability
Quenched by electron donors
Very hydrophilic
Good solubility in polar solvents
Zwitterionic dye
Molar Mass: 631 g/mol

ATTO 680 Datasheet

ATTO 680 Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 680 nm

λ_em = 700 nm

ε_max = 1.25×10⁵

Φ_f = 0.30

τ_fl = 1.7 ns

Brightness = 37.5

Laser = 633 – 676 nm

Filter set = Cy®5.5

ATTO 655

Overview:

High fluorescence yield
High thermal and photostability
Excellent ozone resistance
Quenched by electron donors
Very hydrophilic
Good solubility in polar solvents
Zwitterionic dye
Molar Mass: 634 g/mol

ATTO 655 Datasheet

ATTO 655 Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 663 nm

λ_em = 684 nm

ε_max = 1.25×10⁵

Φ_f = 0.30

τ_fl = 1.8 ns

Brightness = 37.5

Laser = 633 – 647 nm

Filter set = Cy®5

ATTO 633

Overview:

High fluorescence yield
High thermal and photostability
Moderately hydrophilic
Good solubility in polar solvents
Stable at pH 4 – 11
Cationic dye, perchlorate salt
Molar Mass: 652.2 g/mol

ATTO 633 Datasheet

ATTO 633 Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 629 nm

λ_em = 657 nm

ε_max = 1.3×10⁵

Φ_f = 0.64

τ_fl = 3.2 ns

Brightness = 83.2

Laser = 633 nm

Filter set = Cy®5

ATTO 594

Overview:

High fluorescence yield
High photostability
Very hydrophilic
Excellent solubility in water
Very little aggregation
New dye with net charge of -1
Molar Mass: 1137 g/mol

ATTO 594 Datasheet

ATTO 594 Fluorophore Excitation and Emission Spectrum

Optical Properties:

λ_ex = 601 nm

λ_em = 627 nm

ε_max = 1.2×10⁵

Φ_f = 0.85

τ_fl = 3.5 ns

Brightness = 102

Laser = 594 nm

Filter set = Texas Red®

ATTO 565

Overview:

High fluorescence yield
High thermal and photostability
Good solubility in polar solvents
Excellent solubility in water
Very little aggregation
Rhodamine dye derivative
Molar Mass: 611 g/mol

ATTO 565 Datasheet

ATTO 565 Fluorophore Excitation and Emission Spectra

Optical Properties:

λ_ex = 563 nm

λ_em = 592 nm

ε_max = 1.2×10⁵

Φ_f = 0.9

τ_fl = 3.4 n

Brightness = 10

Laser = 532 nm

Filter set = TRITC

ATTO 488

Overview:

High fluorescence yield
High photostability
Very hydrophilic
Excellent solubility in water
Very little aggregation
New dye with net charge of -1
Molar Mass: 804 g/mol

ATTO 488 Datasheet

ATTO 488 Fluorophore Excitation and Emission Spectra

Optical Properties:

λ_ex = 501 nm

λ_em = 523 nm

ε_max = 9.0×10⁴

Φ_f = 0.80

τ_fl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

ATTO 390

Overview:

High fluorescence yield
Large Stokes-shift (89 nm)
Good photostability
Moderately hydrophilic
Good solubility in polar solvents
Coumarin derivate, uncharged
Low molar mass: 343.42 g/mol

ATTO 390 Datasheet

ATTO 390 Fluorescent Dye Excitation and Emission Spectra

Optical Properties:

λ_ex = 390 nm

λ_em = 479 nm

ε_max = 2.4×10⁴

Φ_f = 0.90

τ_fl = 5.0 ns

Brightness = 21.6

Laser = 365 or 405 nm

APC (Allophycocyanin)

Overview:

High quantum yield
Large phycobiliprotein
6 chromophores per molecule
Isolated from red algae
Molecular Weight: 105 kDa

APC Datasheet

APC Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 650 nm

λ_em = 660 nm

ε_max = 7.0×10⁵

Φ_f = 0.68

Brightness = 476

Laser = 594 or 633 nm

Filter set = Cy®5

Streptavidin

Properties:

Homo-tetrameric protein purified from Streptomyces avidinii which binds four biotin molecules with extremely high affinity
Molecular weight: 53 kDa
Formula: C₁₀H₁₆N₂O₃S
Applications: Western blot, immunohistochemistry, and ELISA

Streptavidin Datasheet

Biotin

Properties:

Binds tetrameric avidin proteins including Streptavidin and neuravidin with very high affinity
Molar mass: 244.31 g/mol
Formula: C₁₀H₁₆N₂O₃S
Applications: Western blot, immunohistochemistry, and ELISA

Biotin Datasheet

HRP (Horseradish peroxidase)

Properties:

Enzymatic activity is used to amplify weak signals and increase visibility of a target
Readily combines with hydrogen peroxide (H₂O₂) to form HRP-H₂O₂ complex which can oxidize various hydrogen donors
Catalyzes the conversion of:
- Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
- Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
- Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
High turnover rate enables rapid generation of a strong signal
44 kDa glycoprotein
Extinction coefficient: 100 (403 nm)
Applications: Western blot, immunohistochemistry, and ELISA

HRP Datasheet

AP (Alkaline Phosphatase)

Properties:

Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
Catalyzes the conversion of:
- Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
- Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
Molecular weight: 140 kDa
Applications: Western blot, immunohistochemistry, and ELISA

AP Datasheet

R-PE (R-Phycoerythrin)

Overview:

Broad excitation spectrum
High quantum yield
Photostable
Member of the phycobiliprotein family
Isolated from red algae
Excellent solubility in water
Molecular Weight: 250 kDa

R-PE Datasheet

R-PE Fluorophore Excitation and Emission Spectra

Optical Properties:

λ_ex = 565 nm

λ_em = 575 nm

ε_max = 2.0×10⁶

Φ_f = 0.84

Brightness = 1.68 x 10³

Laser = 488 to 561 nm

Filter set = TRITC

Properties

Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide
Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Purification	Protein A purified
Clonality	Polyclonal
Specificity	Detects ~83kDa.
Cite This Product	StressMarq Biosciences Cat# SPC-405, RRID: AB_10640369
Certificate of Analysis	1 µg/ml of SPC-405 was sufficient for detection of gamma-ENaC in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names	SCNN1G Antibody, Epithelial Sodium Channel gamma Antibody, Amiloride sensitive epithelial sodium channel gamma subunit Antibody, Amiloride sensitive sodium channel subunit gamma Antibody, Amiloride-sensitive sodium channel subunit gamma Antibody, BESC3 Antibody, ENaC gamma subunit Antibody, ENaCG Antibody, ENaCgamma Antibody, Epithelial Na(+) channel subunit gamma Antibody, Epithelial Na+ channel subunit gamma Antibody, Gamma ENaC Antibody, Gamma NaCH Antibody, Gamma-ENaC Antibody, Gamma-NaCH Antibody, Nonvoltage gated sodium channel 1 subunit gamma Antibody, Nonvoltage-gated sodium channel 1 subunit gamma Antibody, PHA 1 Antibody, PHA1 Antibody, SCNEG Antibody, SCNN 1G Antibody, SCNN1G Antibody, SCNNG_HUMAN Antibody, Sodium channel non voltage gated 1 gamma subunit Antibody, Sodium channel nonvoltage gated 1 gamma Antibody
Research Areas	Epithelial Sodium Channels (ENaC), Ion Channels, Neuroscience, Sodium Channels
Cellular Localization	Apical cell membrane
Accession Number	NP_058742
Gene ID	24768
Swiss Prot	P37091
Scientific Background	The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, α, β, and γ. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
References	1. Kakizoe Y., et al. (2009) J Hpyertens. 27(8): 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216(2):453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285(4): F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118(4): 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293(3): L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94(1): 120-128.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-ENaC Polyclonal Antibody (SPC-405). Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-405) at 1:100. Secondary Antibody: FITC Goat Anti-Rabbit (green).</p>

Immunohistochemistry analysis using Rabbit Anti-ENaC Polyclonal Antibody (SPC-405). Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-405) at 1:100. Secondary Antibody: FITC Goat Anti-Rabbit (green).

<p>Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody (SPC-405). Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-405) at 1:1000.</p>

Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody (SPC-405). Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-405) at 1:1000.

<p>Western blot analysis of Mouse kidney cortex showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody (SPC-405). Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-405) at 1:1000. Low-salt diet (lanes 1-4) compared to a high-salt diet (lanes 5-7). 70kDa degradation band observed in low-salt.</p>

Western blot analysis of Mouse kidney cortex showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody (SPC-405). Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-405) at 1:1000. Low-salt diet (lanes 1-4) compared to a high-salt diet (lanes 5-7). 70kDa degradation band observed in low-salt.

Product Citations (32)

Western Blot

Enac Regulation in the Kidney: the Role of Ankyrin G

Klemens, C.A. (2017) University of Pittsburgh. PhD Dissertation.

PubMed ID: N/A Reactivity Rat Applications: Western Blot

Hypokalemia and Pendrin Induction by Aldosterone.

Xu, N. et al. (2017) Hypertension. 69(5):855-862.

PubMed ID: 28289181 Reactivity Mouse Applications: Western Blot

Derlin-1 promotes ubiquitination and degradation of epithelial sodium channel (ENaC).

You, H. et al. (2017) J Cell Sci. 130(6):1027-1036.

PubMed ID: 28137758 Reactivity Mouse Applications: Western Blot

Derlin-1 promotes ubiquitination and degradation of epithelial sodium channel (ENaC).

You, H. et al. (2017) J Cell Sci. 130(6):1027-1036.

PubMed ID: 28137758 Reactivity Human Applications: Western Blot

Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC).

Klemens, C.A., Edinger, R.S., Kightlinger, L., Liu, X. and Butterworth, M.B. (2016) J Biol Chem. 292(1):375-385.

PubMed ID: 27895120 Reactivity Mouse Applications: Western Blot

Renal sodium transport in renin-deficient Dahl salt-sensitive rats.

Pavlov, T.S., Levchenko, V., Ilatovskaya, D.V., Moreno, C. and Staruschenko, A. (2016) J Renin Angiotensin Aldosterone Syst. 17(3).

PubMed ID: 27443990 Reactivity Rat Applications: Western Blot

(Pro)Renin Receptor Regulates Potassium Homeostasis through a Local Mechanism.

Xu, C. et al. (2016) Am J Physiol Renal Physiol. [Epub ahead of print]

PubMed ID: 27440776 Reactivity Rat Applications: Western Blot

SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.

Ferdaus, M.Z. et al. (2016) J Physiol. 594(17):4945-66.

PubMed ID: 27068441 Reactivity Mouse Applications: Western Blot

Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport.

Ramkumar, N. et al. (2016) Am J Physiol Renal Physiol. 311(1):F186-94.

PubMed ID: 27053687 Reactivity Mouse Applications: Western Blot

The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.

Patel-Chamberlin, M. et al. (2016) PLoS One. 11(3):e0150918.

PubMed ID: 26963391 Reactivity Mouse Applications: Western Blot

Hyperuricemia induced hypertension through activation of renal epithelial sodium channel (ENaC).

Xu, W. et al. (2016) Metabolism. 65(3):73-83.

PubMed ID: 26892518 Reactivity Rat Applications: Western Blot

The Thiazide-Sensitive Co-Transporter Promotes the Development of Sodium Retention in Mice with Diet-Induced Obesity.

Davies, M. R. P. et al. (2015) Kidney Blood Press Res. 40(5):509-519.

PubMed ID: 26418861 Reactivity Mouse Applications: Western Blot

Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease.

Zhang, Y. et al. (2015) Sci Rep. 5:12480.

PubMed ID: 26207612 Reactivity Mouse Applications: Western Blot

Compositions And Methods Of Use For (PRO)Renin Receptor .

Feng, Y. and Yang, T. (2015) United States Patent Application 20150025013.

PubMed ID: N/A Reactivity Rat Applications: Western Blot

Intersubunit conformational changes mediate epithelial sodium channel gating.

Collier, D.M., Tomkovicz, V.R., Peterson, Z.J., Benson, C.J., and Snyder, P.M. (2014) J Gen Physiol. 144(4):337-48.

PubMed ID: 25225551 Reactivity Human Applications: Western Blot

Role of Rho GDP-dissociation inhibitor alpha in control of ENaC-mediated sodium reabsorption.

Pavlov, T. S., Levchenko, V. and Staruschenko, A. (2014) J Biol Chem. 289(41):28651-9.

PubMed ID: 25164814 Reactivity Mouse Applications: Western Blot

Collecting duct specific knock-out of renin attenuates angiotensin-II induced hypertension.

Ramkumar, N. et al. (2014) Am J Physiol Renal Physiol. 307(8):F931-8.

PubMed ID: 25122048 Reactivity Mouse Applications: Western Blot

Novel Mechanisms of Sodium Retention in Obesity: Phosphorylation of NKCC2 and Regulation of SPAK/OSR1 by AMPK.

Davies, M. R. P. et al. (2014) Am J Physiol. 307(1):F96-F106.

PubMed ID: 24808538 Reactivity Mouse Applications: Western Blot

Double Knockout of Carbonic Anhydrase II (CAII) and Na+-Cl- Cotransporter (NCC) Causes Salt Wasting and Volume Depletion.

Xu, J., Barone, S., Brooks, M.B., Soleimani, M. (2013) Cell Physiol Biochem. 32(suppl 1):173-183.

PubMed ID: 24429824 Reactivity Mouse Applications: Western Blot

Adenylyl Cyclase VI Mediates Vasopressin-Stimulated ENaC Activity.

Roos, K.P. et al. (2012) JASN. 24 (2): 218-227.

PubMed ID: 23264685 Reactivity Mouse Applications: Western Blot

Regional differences in rat conjunctival ion transport activities.

Yu, D. et al. (2012) Am J Physiol Cell Physiol. 303 (7): 767-780.

PubMed ID: 22814399 Reactivity Xenopus laevis Applications: Western Blot

The Epithelial Sodium Channel (ENaC) Establishes a Trafficking Vesicle Pool Responsible for Its Regulation.

Edinger, R.S. et al. (2012) PLoS ONE. 7(9): e46593.

PubMed ID: 23029554 Reactivity Mouse Applications: Western Blot

Double Knockout of pendrein and NaCl cotransporter (NCC) causes severe salt wasting, volume depletion and renal failure.

Soleimani, M. et al. (2012) Proc Natl Acad Sci U S A. 109 (33): 13368-13373.

PubMed ID: 22847418 Reactivity Mouse Applications: Western Blot

Aldosterone does not require angiotensin II to activate NCC through a WNK4–SPAK–dependent pathway.

van der Lubbe, N. et al. (2012) Euro J Physiol. 463 (6): 853-863.

PubMed ID: 22549242 Reactivity Rat Applications: Western Blot

Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex.

Ilatovskaya, D.V., Pavlov, T.S., Levchenko, V., Negulyaev, Y.A. and Staruschenko, A. (2011) FASEB J. 25 (8): 2688-2699.

PubMed ID: 21536685 Reactivity Hamster Applications: Western Blot

Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex.

Ilatovskaya, D.V., Pavlov, T.S., Levchenko, V., Negulyaev, Y.A. and Staruschenko, A. (2011) FASEB J. 25 (8): 2688-2699.

PubMed ID: 21536685 Reactivity Mouse Applications: Western Blot

Immunohistochemistry

Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.

Reed-Geaghan, E.G. et al. (2016) J Neurosci. 36(15):4362-76.

PubMed ID: 27076431 Reactivity Mouse Applications: Immunohistochemistry

Epoxyeicosatrienoic Acid (EET) Analog Lowers Blood Pressure Through Vasodilation And Sodium Channel Inhibition.

Khan, M. A., et al. (2014) Clin Sci (Lond). 127(7):463-74.

PubMed ID: 24707975 Reactivity Rat Applications: Immunohistochemistry

ENaC γ-expressing astrocytes in the circumventricular organs, white matter, and ventral medullary surface: sites for Na+ regulation by glial cells.

Miller, R.L. and Loewy, A.D. (2013) J Chem Neuroanat. 53:72-80.

PubMed ID: 24145067 Reactivity Rat Applications: Immunohistochemistry

Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct.

Pavlov, T.S. et. al. (2013) FASEB J. 27(7):2723-32.

PubMed ID: 23558339 Reactivity Mouse Applications: Immunohistochemistry

Other Citations

ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.

Zhang, C. et al. (2016) Am J Physiol Renal Physiol. [Epub ahead of print]

PubMed ID: N/A

Prostasin interacts with the epithelial sodium channel and facilitates cleavage of the gamma subunit by a second protease.

Carattino, M.D. et al. (2014) Am J Physiol Renal Physiol. 307(9):F1080-7.

PubMed ID: 25209858 Reactivity Xenopus

AP (Alkaline Phosphatase)

Properties:

Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
Catalyzes the conversion of:
- Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
- Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
Molecular weight: 140 kDa
Applications: Western blot, immunohistochemistry, and ELISA

AP Datasheet

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