StressMarq/DMPO/SIH-324-25MG/25-mg
商品编号：
SIH-324-25MG
市场价：
¥600.00
美元价：
360.00
产品分类：
电泳缓冲液
公司分类：
Electrophoretic_buffer
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | DMPO |
| Description | Spintrappingreagent |
| Purity | >98% |
| CASNo. | 3317-61-1 |
| MolecularFormula | C6H11NO |
| MolecularWeight | 113.16,13.16 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Agent |
| Solubility | Solubleto100mMinethanolandto100mMinDMSO |
| Source | Synthetic |
| Appearance | ColorlessSolid |
| SMILES | CC1(CCC=[N+]1[O-])C |
| InChI | InChI=1S/C6H11NO/c1-6(2)4-3-5-7(6)8/h5H,3-4H2,1-2H3 |
| InChIKey | VCUVETGKTILCLC-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Harmful.Maybeharmfulifinhaled,swallowedorabsorbedthroughskin.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-Avoidcontactwithshinandeyes |
| CiteThisProduct | DMPO(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-324) |
BIOLOGicalDescription
| AlternativeNames | 2,2-Dimethyl-3,4-dihydro-2H-pyrrole1-oxide,5,5-Dimethyl-1-Pyrroline-N-Oxide,3,4-dihydro-2,3-dimethyl-2H-pyrrole1-oxide |
| ResearchAreas | Cancer,OxidativeStress |
| PubChemID | 1774 |
| ScientificBackground | TheformationoffreerADIcalsandotherhighlyreactiveoxygenspecieshasbeenimplicatedinthepathogenesisofmanydiseasestates(1).TheABIlitytoidentifythesespeciesiscrucial,andspintrappinghasaccomplishedthisgoal.DMPO(5,5-dimethyl-1-pyrrolineN-oxide)isoneoftheleasttoxictocellsandanimals,andpossessesconvenientpharmacokinetics(uptake,distribution,metabolismandexcretion)inbiologicalsystems(2-6).RecentstudieshavedeterminedthatnitricoxidemaysubstantiallyaffectthequantitativedeterminationofDMPOadducts,andthereforeextracautionisrequiredwhenstudyinggenerationofthesespeciesinthepresenceofnitricoxideoritsradicals(1).DMPOadductscanbegeneratedwithproteinandDNAradicals(7). |
| References | 1. ReszkaK.J.,etal.(2006)NitricOxide15:133-141. 2.RamirezD.C.,Gomez-MejibaS.E.,andMasonR.P.(2007)NatProtoc.2(3):512-522. 3.KhanN.,etal.(2003)FreeRadic.Biol.Med34:1473–1481. 4.HaseloffR.F.,etal.(1997)FEBSLett418:73–75. 5.SchaeferC.F.,JanzenE.G.,WestM.S.,PoyerJ.L.,andKosankeS.D.(1996)FreeRadic.Biol.Med21:427–436. 6.AnzaiK.,etal.(2003)Arch.Biochem.Biophys415:251–256. 7.ChatterjeeS.,Ehrenshaft,M.,Bhattacharjee,S.,Derterding,L.J.,Bonini,M.G.,Corbett,J.,Kadiiska,M.B.,TomerK.B.andMason,R.P.2009FreeRadic.Med.andBiol.46:454-461. |
ProductImages
ChemicalstructureofDMPO(SIH-324),aNitroneadductformation.CAS#:3317-61-1.MolecularFormula:C6H11NO.MolecularWeight:13.16g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
