StressMarq/DAPT/SIH-378-5MG/5-mg
商品编号：
SIH-378-5MG
市场价：
¥1620.00
美元价：
972.00
产品分类：
电泳缓冲液
公司分类：
Electrophoretic_buffer
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | DAPT |
| Description | γ-secretaseinhibitor |
| Purity | >99% |
| CASNo. | 208255-80-5 |
| MolecularFormula | C23H26F2N2O4 |
| MolecularWeight | 432.46 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleto100mMinDMSO |
| Source | Synthetic |
| Appearance | Whitetooff-whitepowder |
| SMILES | [[email protected]](NC(=O)[[email protected]@H](NC(=O)CC1=CC(=CC(=C1)F)F)C)(C2=CC=CC=C2)C(OC(C)(C)C)=O |
| InChI | InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1 |
| InChIKey | DWJXYEABWRJFSP-XOBRGWDASA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-Donotbreathedust.S24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | DAPT(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-378) |
BIOLOGicalDescription
| AlternativeNames | N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester |
| ResearchAreas | CellSignaling,Neuroscience |
| PubChemID | 5311272 |
| ScientificBackground | Inhibitorofγ-secretase;causesareductioninAβ40andAβ42levelsinhumanprimaryneuronalcultures(IC50valuesare115and200nMfortotalAβandAβ42respectively)andinbrainextract,cerebrospinalfluidandplasmainvivo.DoesnotaffectAPPαandAPPβlevels.BlocksNotchsignalinginhybridhuman-mousefetalthymusorganculture(FTOC).Activitycausesneuralcellstocommittoneuronaldifferentiation. |
| References | 1.DoveyH.F.,etal.(2001)J.NeuRochem.76(1):173-81. 2.DeSmedtM.,etal.(2005)Blood.106(10):3498-506. 3.KanungoJ.,etal.(2008)J.Neurochem.106(5):2236-48. |
ProductImages
ChemicalstructureofDAPT(SIH-378),aγ-secretaseinhibitor.CAS#:208255-80-5.MolecularFormula:C23H26F2N2O4.MolecularWeight:432.46g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
