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当前位置： 首页 > 产品中心 > Electrophoretic_buffer > 应激MARQ/抗Cox 2抗体/SPC-1321D-A594/100-µl
商品详细应激MARQ/抗Cox 2抗体/SPC-1321D-A594/100-µl
应激MARQ/抗Cox 2抗体/SPC-1321D-A594/100-µl
应激MARQ/抗Cox 2抗体/SPC-1321D-A594/100-µl
商品编号： SPC-1321D-A594
市场价： ¥6040.00
美元价： 3624.00
产地： 美国(厂家直采)
公司：
产品分类： 电泳缓冲液
公司分类： Electrophoretic_buffer
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

ProductNameCox2Antibody
Description

RabbitAnti-HumanCox2Polyclonal

SpeciesReactivityHuman,Mouse,Rat
ApplicationsWB,IHC,ICC/IF,ELISA
AntibodyDilutionWB(1:1000),IHC(1:100),ICC/IF(1:500),ELISA(1:20000);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenSynthesizedpeptidederivedfromhumanCox2.
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,150mMNaCl,0.02%sodiumazide
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
ClonalityPolyclonal
IsotypeIgG
SpecificityDetectsendogenouslevelsoftotalCox2protein.
CiteThisProductStressMarqBiosciencesCat#SPC-1321,RRID:AB_2713565
CertificateofAnalysisA1:1000dilutionofSPC-1321wassufficientfordetectionofCox2in10µgofA549celllysatesbyECLimmunoblotanalysisusingGoatAnti-RabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesCOX2antibody,COX3antibody,Cyclooxygenase1antibody,PCOX1antibody,PGG/HSantibody,PGHsynthase2antibody,PGHS1antibody,PHSIIantibody,Prostaglandinendoperoxidesynthase1antibody,Prostaglandinendoperoxidesynthase2antibody,PTGS2antibody,TIS10antibody
CellularLocalizationEndoplasmicreticulummembrane,MicrosomeMembrane
AccessionNumberNP_000954.1
GeneID5743
SwissProtP35354
ScientificBackgroundCyclooxygenase(COX),alsoknownasProstaglandinH2synthaseandProstaglandinendoperoxidesynthase,isakeyenzymeintheofconversionarachidonicacidtoProstaglandinH2.ProstaglandinH2isconvertedbyotherenzymesintoinflammatorymediatorsprostaglandin(PG)D2,PGE2,PGF2a,PGI2andThromboxaneA2.Thus,COXisakeyenzymeintheproductionofinflammatoryagentsandisthetargetofintenseresearchanddrugdiscoveryactivities.TherearetwoenzymesofCOX,COX1andCOX2.COX2isfoundinelevatedlevelsinsynoviocytesfromrheumatoidarthritispatients.ThediscomfortsofinflammationsuchaspainandswellingarelargelyduetotheactionofprostaglandinsproducedbyCOX-2.COX2(Cyclooxygenase2)isaninducIBLeenzyme.Itisinvolvedintheresponseofcellstogrowthfactors,tumorpromoters,andcytokinesthatinduceitsexpression.Givenitsroleinsynthesizingprostaglandins,COX2isthereforeofinterestinstudyingimmuneresponseregulation.COX2isinducedbyawidevarietyofstimuliandwasinitiallyidentifiedasimmediateearlygrowthresponsegene.Inaddition,COX2expressionmarkedlyincreasedin85-90%ofhumancolorectaladenocarcinomawhereasCOX1levelsremainunchanged.
References1.JonesD.A.etal.(1993)J.Biol.Chem.268:9049-9054.
2.KosakaT.etal.(1994)Eur.J.Biochem.221:889-897.
3.ApplebyS.B.etal.(1994)Biochem.J.302:723-727.
4.BarnettJ.etal.(1994)Biochim.Biophys.Acta1209:130-139.

ProductImages

<p>Immunohistochemistry analysis using Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321). Tissue: Breast Carcinoma Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321) at 1:100. The image on the right is treated with the synthesized peptide.</p>

ImmunohistochemistryanalysisusingRabbitAnti-Cox2PolyclonalAntibody(SPC-1321).Tissue:BreastCarcinomaTissue.Species:Human.Fixation:Formalinfixedparaffin-embedded.PrimaryAntibody:RabbitAnti-Cox2PolyclonalAntibody(SPC-1321)at1:100.Theimageontherightistreatedwiththesynthesizedpeptide.

<p>Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321). Tissue: A549. Species: Human. Primary Antibody: Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321) at 1:100. The image on the right is treated with the synthesized peptide.</p>

Immunocytochemistry/ImmunofluorescenceanalysisusingRabbitAnti-Cox2PolyclonalAntibody(SPC-1321).Tissue:A549.Species:Human.PrimaryAntibody:RabbitAnti-Cox2PolyclonalAntibody(SPC-1321)at1:100.Theimageontherightistreatedwiththesynthesizedpeptide.

<p>Western blot analysis of Human A549 cell lysates showing detection of ~74kDa Cox2 protein using Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321). Lane 1: Human A549. Lane 2: Human A549 treated with the immunizing peptide. Primary Antibody: Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321) at 1:1000. Predicted/Observed Size: ~74kDa.</p>

WesternblotanalysisofHumanA549celllysatesshowingdetectionof~74kDaCox2proteinusingRabbitAnti-Cox2PolyclonalAntibody(SPC-1321).Lane1:HumanA549.Lane2:HumanA549treatedwiththeimmunizingpeptide.PrimaryAntibody:RabbitAnti-Cox2PolyclonalAntibody(SPC-1321)at1:1000.Predicted/ObservedSize:~74kDa.

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 ATTO594
Overview:
  • Highfluorescenceyield
  • HighphotostABIlity
  • Veryhydrophilic
  • Excellentsolubilityinwater
  • Verylittleaggregation
  • Newdyewithnetchargeof-1
  • MolarMass:1137g/mol

ATTO594Datasheet

 ATTO 594 Fluorophore Excitation and Emission SpectrumOpticalProperties:

λex =601 nm

λem=627nm

εmax=1.2×105

Φf= 0.85

τfl =3.5ns

Brightness=102

Laser =594nm

Filterset =TexasRed®

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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CLIA套件 兴奋剂 敌手 抑制剂 蛋白质 活化剂 抗氧化剂 氧化还原探针 多克隆
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