应激MARQ/抗Cox 2抗体/SPC-1321D-A594/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细应激MARQ/抗Cox 2抗体/SPC-1321D-A594/100-µl

应激MARQ/抗Cox 2抗体/SPC-1321D-A594/100-µl

商品编号： SPC-1321D-A594

品牌： StressMarq Biosciences

市场价： ¥6040.00

美元价： 3624.00

产地：美国(厂家直采)

公司：

产品分类：电泳缓冲液

公司分类： Electrophoretic_buffer

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName Cox2Antibody

Description

RabbitAnti-HumanCox2Polyclonal

SpeciesReactivity Human,Mouse,Rat

Applications WB,IHC,ICC/IF,ELISA

AntibodyDilution WB(1:1000),IHC(1:100),ICC/IF(1:500),ELISA(1:20000);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen SynthesizedpeptidederivedfromhumanCox2.

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,150mMNaCl,0.02%sodiumazide
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	AffinityPurified
Clonality	Polyclonal
Isotype	IgG
Specificity	DetectsendogenouslevelsoftotalCox2protein.
CiteThisProduct	StressMarqBiosciencesCat#SPC-1321,RRID:AB_2713565
CertificateofAnalysis	A1:1000dilutionofSPC-1321wassufficientfordetectionofCox2in10µgofA549celllysatesbyECLimmunoblotanalysisusingGoatAnti-RabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	COX2antibody,COX3antibody,Cyclooxygenase1antibody,PCOX1antibody,PGG/HSantibody,PGHsynthase2antibody,PGHS1antibody,PHSIIantibody,Prostaglandinendoperoxidesynthase1antibody,Prostaglandinendoperoxidesynthase2antibody,PTGS2antibody,TIS10antibody
CellularLocalization	Endoplasmicreticulummembrane,MicrosomeMembrane
AccessionNumber	NP_000954.1
GeneID	5743
SwissProt	P35354
ScientificBackground	Cyclooxygenase(COX),alsoknownasProstaglandinH2synthaseandProstaglandinendoperoxidesynthase,isakeyenzymeintheofconversionarachidonicacidtoProstaglandinH2.ProstaglandinH2isconvertedbyotherenzymesintoinflammatorymediatorsprostaglandin(PG)D2,PGE2,PGF2a,PGI2andThromboxaneA2.Thus,COXisakeyenzymeintheproductionofinflammatoryagentsandisthetargetofintenseresearchanddrugdiscoveryactivities.TherearetwoenzymesofCOX,COX1andCOX2.COX2isfoundinelevatedlevelsinsynoviocytesfromrheumatoidarthritispatients.ThediscomfortsofinflammationsuchaspainandswellingarelargelyduetotheactionofprostaglandinsproducedbyCOX-2.COX2(Cyclooxygenase2)isaninducIBLeenzyme.Itisinvolvedintheresponseofcellstogrowthfactors,tumorpromoters,andcytokinesthatinduceitsexpression.Givenitsroleinsynthesizingprostaglandins,COX2isthereforeofinterestinstudyingimmuneresponseregulation.COX2isinducedbyawidevarietyofstimuliandwasinitiallyidentifiedasimmediateearlygrowthresponsegene.Inaddition,COX2expressionmarkedlyincreasedin85-90%ofhumancolorectaladenocarcinomawhereasCOX1levelsremainunchanged.
References	1.JonesD.A.etal.(1993)J.Biol.Chem.268:9049-9054. 2.KosakaT.etal.(1994)Eur.J.Biochem.221:889-897. 3.ApplebyS.B.etal.(1994)Biochem.J.302:723-727. 4.BarnettJ.etal.(1994)Biochim.Biophys.Acta1209:130-139.

ProductImages

<p>Immunohistochemistry analysis using Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321). Tissue: Breast Carcinoma Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321) at 1:100. The image on the right is treated with the synthesized peptide.</p>

ImmunohistochemistryanalysisusingRabbitAnti-Cox2PolyclonalAntibody(SPC-1321).Tissue:BreastCarcinomaTissue.Species:Human.Fixation:Formalinfixedparaffin-embedded.PrimaryAntibody:RabbitAnti-Cox2PolyclonalAntibody(SPC-1321)at1:100.Theimageontherightistreatedwiththesynthesizedpeptide.

<p>Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321). Tissue: A549. Species: Human. Primary Antibody: Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321) at 1:100. The image on the right is treated with the synthesized peptide.</p>

Immunocytochemistry/ImmunofluorescenceanalysisusingRabbitAnti-Cox2PolyclonalAntibody(SPC-1321).Tissue:A549.Species:Human.PrimaryAntibody:RabbitAnti-Cox2PolyclonalAntibody(SPC-1321)at1:100.Theimageontherightistreatedwiththesynthesizedpeptide.

<p>Western blot analysis of Human A549 cell lysates showing detection of ~74kDa Cox2 protein using Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321). Lane 1: Human A549. Lane 2: Human A549 treated with the immunizing peptide. Primary Antibody: Rabbit Anti-Cox2 Polyclonal Antibody (SPC-1321) at 1:1000. Predicted/Observed Size: ~74kDa.</p>

WesternblotanalysisofHumanA549celllysatesshowingdetectionof~74kDaCox2proteinusingRabbitAnti-Cox2PolyclonalAntibody(SPC-1321).Lane1:HumanA549.Lane2:HumanA549treatedwiththeimmunizingpeptide.PrimaryAntibody:RabbitAnti-Cox2PolyclonalAntibody(SPC-1321)at1:1000.Predicted/ObservedSize:~74kDa.

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ATTO594

Overview:

Highfluorescenceyield
HighphotostABIlity
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation
Newdyewithnetchargeof-1
MolarMass:1137g/mol

ATTO594Datasheet

ATTO 594 Fluorophore Excitation and Emission Spectrum

OpticalProperties:

λ_ex =601 nm

λ_em=627nm

ε_max=1.2×10⁵

Φ_f= 0.85

τ_fl =3.5ns

Brightness=102

Laser =594nm

Filterset =TexasRed®

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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