StressMarq/CHIR99021/SIH-437-1MG/1-mg
商品编号：
SIH-437-1MG
市场价：
¥1100.00
美元价：
660.00
产品分类：
电泳缓冲液
公司分类：
Electrophoretic_buffer
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | CHIR99021 |
| Description | GSK3βkinaseinhibitor |
| Purity | >98%(HPLC) |
| CASNo. | 252917-06-9 |
| MolecularFormula | C22H18Cl2N8 |
| MolecularWeight | 465.3 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleto20mMinDMSO |
| Source | Synthetic |
| Appearance | Whitetolightbrownsolid |
| SMILES | CC1=CNC(=N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N |
| InChI | InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32) |
| InChIKey | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Acutetoxicity,Oral(Category2),H300Skinirritation(Category2),H315Eyeirritation(Category2A),H319Specifictargetorgantoxicity-singleexposure(Category3),Respiratorysystem,H335SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H300Fatalifswallowed.H315Causesskinirritation.H319Causesseriouseyeirritation.H335Maycauserespiratoryirritation.Precautionarystatements:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P271Useonlyoutdoorsorinawell-ventilatedarea.P280Wearprotectivegloves/eyeprotection/faceprotection.P301+P310IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physician.P302+P352IFONSKIN:Washwithplentyofsoapandwater.P304+P340IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P321Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P330Rinsemouth.P332+P313Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313Ifeyeirritationpersists:Getmedicaladvice/attention.P362Takeoffcontaminatedclothingandwashbeforereuse.P403+P233Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant. |
| CiteThisProduct | CHIR99021(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-437) |
BIOLOGicalDescription
| AlternativeNames | CT99021,6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 9956119 |
| ScientificBackground | CHIR99021isapotentandhighlyselectiveglycogensynthasekinase3(GSK-3)inhibitor.Italsopromotesself-renewalofmouseandhumanESCduetoβ-cateninandc-MycproteinlevelstABIlization. |
| References | 1.YeS.,etal.(2012)PloSOne7(4):e35892. 2.RingD.B.,etal.(2003).Diabetes.52(3):588–595. |
ProductImages
ChemicalstructureofCHIR99021(SIH-437),aGSK3betakinaseinhibitor.CAS#:252917-06-9.MolecularFormula:C22H18Cl2N8.MolecularWeight:465.3g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
