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当前位置: 首页 > 产品中心 > Electrophoretic_buffer > StressMarq/Anti-Cdc7 Antibody (pThr376)/SPC-934D/100-µl
商品详细StressMarq/Anti-Cdc7 Antibody (pThr376)/SPC-934D/100-µl
StressMarq/Anti-Cdc7 Antibody (pThr376)/SPC-934D/100-µl
StressMarq/Anti-Cdc7 Antibody (pThr376)/SPC-934D/100-µl
商品编号: SPC-934D
市场价: ¥5900.00
美元价: 3540.00
产地: 美国(厂家直采)
公司:
产品分类: 电泳缓冲液
公司分类: Electrophoretic_buffer
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameCdc7Antibody(pThr376)
Description

RabbitAnti-HumanCdc7(pThr376)Polyclonal

SpeciesReactivityHuman
ApplicationsWB,AM
AntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenAphospho-specificpeptidecorrespondingtoresiduessurroundingThr376ofhumanCdc7(AA373-379)
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationPeptideAffinityPurified
ClonalityPolyclonal
SpecificityDetects63.888kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-934,RRID:AB_2707211
CertificateofAnalysisA1:250dilutionofSPC-934wassufficientfordetectionofCdc7(pThr376)in10µgofhumanbreastcancercell(MCF7)lysatesbyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesCDC7celldivisioncycle7like1Antibody,Celldivisioncycle7kinaseAntibody,HsCdc7Antibody,Hsk1Antibody,HuCDC7Antibody
ResearchAreasCancer,CellCycle,CellSignaling,EpigeneticsandNuclearSignaling,ProteinPhosphorylation
CellularLocalizationNucleus
AccessionNumberNP_003494
GeneID8317
SwissProtO00311
ScientificBackgroundTheDbf4/Cdc7proteinkinaseisessentialfortheactivationofreplicationoriginsduringSphase.Cdc7/Dbf4efficientlyphosphorylatesseveralproteinsthatarerequiredfortheinitiationofDNAreplication,includingfiveofthesixminichromosomemaintenance(Mcm)proteinsandthep180subunitofDNApolymerasea-primase.ThisproteincomplexconsistsofthecatalyticsubunitCdc7associatingwiththeregulatoryandactivatingsubunitDbf4.Thekinaseactivityofthecomplexisregulatedthroughoutthecellcycle,mainlybyfluctuatinglevelsofDbf4.Cdc7isconsistentlyexpressedthroughoutthecellcycle,whiletheexpressionofDbf4isabsentduringG1phaseandaccumulatesduringSandG2phases.Theanaphase-promotingcomplexrapidlydegradesDbf4atthetimeofchromosomesegregation,andthestABIlityofDbf4remainslowduringpre-StartG1phase.ThecoordinateddegradationofDbf4andthetimeofchromosomeseparationisimportanttoensuringthatprereplicativecomplexes,whichassembleafterchromosomesegregation,donotimmediatelyrefire.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。