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当前位置: 首页 > 产品中心 > Electrophoretic_buffer > StressMarq/CDC37 Protein/SPR-304B/100-µg
商品详细StressMarq/CDC37 Protein/SPR-304B/100-µg
StressMarq/CDC37 Protein/SPR-304B/100-µg
StressMarq/CDC37 Protein/SPR-304B/100-µg
商品编号: SPR-304B
市场价: ¥6380.00
美元价: 3828.00
产地: 美国(厂家直采)
公司:
产品分类: 电泳缓冲液
公司分类: Electrophoretic_buffer
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameCDC37Protein
Description

HumanRecombinantCDC37Protein

ApplicationsWB,SDS-PAGE,FunctionalAssay
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesHistag

Properties

StorageBuffer25mMTrisbufferpH7.2,150mMNaCl,0.1DTT,50%glycerol
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
Specificity~445kDa
CiteThisProductHumanRecombinantCDC37Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-304)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDSPAGEanalysis.4uMSPR-303,whenaddedto2uMSPR-300(Aha1)-activatedHSP90(2uM;His-taggedHSP90beta)in33mMHepespH7.2,30mMNaCl,5mMMgCl2,1mMDTT,1.5mMATPina100ulreactionat37degreesC,eliminatedallAha1-mediatedATPasestimulationaswellasintrinsicHSP90ATPaseactivity.(Thisisanenzyme-linkedATPregenerationassaytrackinglossofNADHabsorbanceat340nm).

BIOLOGicalDescription

ResearchAreasCancer,HeatShock,CellSignaling,Epigenetics
CellularLocalizationCytoplasm
AccessionNumberNP_008996.1
GeneID11140
SwissProtQ16543
ScientificBackgroundHSP90co-chaperoneCdc37isaproteinthatisencodedbytheCDC37gene.IthasbeenfoundtoformcomplexeswithHSP90andavarietyofproteinkinasesincludingCDK4,CDK6,SRC,RAF1,MOKandelF-2alphakinases.ItisthoughttoplayacriticalroleindirectingHSP90toitstargetkinases(1,2).CDC37isnecessaryformaintainingprostatetumorcellgrowthandrepresentsanoveltargetintheexplorationformulti-targetedtherapies(3,4).
References1.DaiK.,KobayashiR.,BeachD.(1996)JBiolChem.271(36):22030-22034.
2.StepanovaL.,LengX.,ParkerS.B.,HarperJ.W.(1996)GenesDev.10(12):1491-1502.
3.KimuraY.,etal.(1997)GenesDev.11(14):1775-1185.
4.GrayP.J.,etal.(2008)NatRevCancer.8(7):491-495.

ProductImages

<p>Western blot showing pull down data for 44.5 kDa human his-tagged CDC37 with 90kDa Hsp90 (SPR-304).</p>

Westernblotshowingpulldowndatafor44.5kDahumanhis-taggedCDC37with90kDaHsp90(SPR-304).

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。