StressMarq/Anti-Caspase 3 Antibody (cleaved)/SPC-1319D-BI/100-µl-免疫在线蚂蚁淘旗下平台

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StressMarq/Anti-Caspase 3 Antibody (cleaved)/SPC-1319D-BI/100-µl

商品编号： SPC-1319D-BI

品牌： StressMarq Biosciences

市场价： ¥5960.00

美元价： 3576.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

Product Name Caspase 3 Antibody (cleaved)

Description

Rabbit Anti-Human Caspase 3 (cleaved) Polyclonal

Species Reactivity Human, Mouse, Rat

Applications WB, IHC

Antibody Dilution WB (1:2000), IHC (200); optimal dilutions for assays should be determined by the user.

Host Species Rabbit

Immunogen Species Human

Immunogen Synthesized peptide derived from human Caspase 3.

Conjugates

Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer	PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Purification	Affinity Purified
Clonality	Polyclonal
Isotype	IgG
Specificity	Detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
Cite This Product	StressMarq Biosciences Cat# SPC-1319, RRID: AB_2713529
Certificate of Analysis	A 1:1000 dilution of SPC-1319 was sufficient for detection of Caspase 3 in 10 µg of COLO cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names	Apopain antibody, CASP-3 antibody, CASP3 antibody, CASP3_HUMAN antibody, Caspase 3 antibody, caspase 3, apoptosis-related cysteine protease antibody, Caspase-3 subunit p12 antibody, CPP 32 antibody, CPP-32 antibody, Cysteine protease CPP32 antibody, PARP cleavage protease antibody, Procaspase 3 antibody, Protein Yama antibody, SCA-1 antibody, SCA1 antibody, SREBP cleavage activity 1 antibody, Yama antibody, Yama protein antibody
Cellular Localization	Cytoplasm
Accession Number	NP_116786.1
Gene ID	836
Swiss Prot	P42574
Scientific Background	Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-3 is activated in the apoptotic cell both by extrinsic (death ligand) and intrinsic (mitochondrial) pathways. The zymogen feature of caspase-3 is necessary because if unregulated, caspase activity would kill cells indiscriminately. Caspase-3 has been found to be necessary for normal brain development as well as its typical role in apoptosis, where it is responsible for chromatin condensation and DNA fragmentation. Elevated levels of a fragment of Caspase-3, p17, in the bloodstream is a sign of a recent myocardial infarction. It is now being shown that caspase-3 may play a role in embryonic and hematopoietic stem cell differentiation.
References	1. Alnemri ES. et al. (1996) Cell 87 (2): 171. 2. Salvesen GS. (2002) Cell Death Differ. 9 (1): 3–5. 3. Ghavami S (2009) J. Med. Genet. 46 (8): 497–510. 4. Porter AG and Jänicke RU (1999) Cell Death Differ. 6 (2): 99–104. 5. Agosto M (2011) J. Am. Coll. Cardiol. 57 (2): 220–1. 6. Abdul-Ghani M. (2008) Cell Stem Cell 2 (6): 515–6.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Tissue: Ehrlich Ascites. Species: Mouse. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:100.</p>

Immunohistochemistry analysis using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Tissue: Ehrlich Ascites. Species: Mouse. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:100.

<p>Western blot analysis of Human COLO cell lysates showing detection of ~17kDa Caspase 3 protein using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Lane 1: Human COLO cell lysate treated with the immunizing peptide. Lane 2: Human COLO cell lysate. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:1000. Predicted/Observed Size: ~17kDa.</p>

Western blot analysis of Human COLO cell lysates showing detection of ~17kDa Caspase 3 protein using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Lane 1: Human COLO cell lysate treated with the immunizing peptide. Lane 2: Human COLO cell lysate. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:1000. Predicted/Observed Size: ~17kDa.

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Biotin

Properties:

Binds tetrameric avidin proteins including Streptavidin and neuravidin with very high affinity
Molar mass: 244.31 g/mol
Formula: C₁₀H₁₆N₂O₃S
Applications: Western blot, immunohistochemistry, and ELISA

Biotin Datasheet

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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