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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-Caspase 3 Antibody (cleaved)/SPC-1319D-A488/100-µl
商品详细StressMarq/Anti-Caspase 3 Antibody (cleaved)/SPC-1319D-A488/100-µl
StressMarq/Anti-Caspase 3 Antibody (cleaved)/SPC-1319D-A488/100-µl
StressMarq/Anti-Caspase 3 Antibody (cleaved)/SPC-1319D-A488/100-µl
商品编号： SPC-1319D-A488
市场价： ¥6040.00
美元价： 3624.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name Caspase 3 Antibody (cleaved)
Description

Rabbit Anti-Human Caspase 3 (cleaved) Polyclonal

Species Reactivity Human, Mouse, Rat
Applications WB, IHC
Antibody Dilution WB (1:2000), IHC (200); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Synthesized peptide derived from human Caspase 3.
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Clonality Polyclonal
Isotype IgG
Specificity Detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
Cite This Product StressMarq Biosciences Cat# SPC-1319, RRID: AB_2713529
Certificate of Analysis A 1:1000 dilution of SPC-1319 was sufficient for detection of Caspase 3 in 10 µg of COLO cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names Apopain antibody, CASP-3 antibody, CASP3 antibody, CASP3_HUMAN antibody, Caspase 3 antibody, caspase 3, apoptosis-related cysteine protease antibody, Caspase-3 subunit p12 antibody, CPP 32 antibody, CPP-32 antibody, Cysteine protease CPP32 antibody, PARP cleavage protease antibody, Procaspase 3 antibody, Protein Yama antibody, SCA-1 antibody, SCA1 antibody, SREBP cleavage activity 1 antibody, Yama antibody, Yama protein antibody
Cellular Localization Cytoplasm
Accession Number NP_116786.1
Gene ID 836
Swiss Prot P42574
Scientific Background Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-3 is activated in the apoptotic cell both by extrinsic (death ligand) and intrinsic (mitochondrial) pathways. The zymogen feature of caspase-3 is necessary because if unregulated, caspase activity would kill cells indiscriminately. Caspase-3 has been found to be necessary for normal brain development as well as its typical role in apoptosis, where it is responsible for chromatin condensation and DNA fragmentation. Elevated levels of a fragment of Caspase-3, p17, in the bloodstream is a sign of a recent myocardial infarction. It is now being shown that caspase-3 may play a role in embryonic and hematopoietic stem cell differentiation.
References 1. Alnemri ES. et al. (1996) Cell 87 (2): 171.
2. Salvesen GS. (2002) Cell Death Differ. 9 (1): 3–5.
3. Ghavami S (2009) J. Med. Genet. 46 (8): 497–510.
4. Porter AG and Jänicke RU (1999) Cell Death Differ. 6 (2): 99–104.
5. Agosto M (2011) J. Am. Coll. Cardiol. 57 (2): 220–1.
6. Abdul-Ghani M. (2008) Cell Stem Cell 2 (6): 515–6.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Tissue: Ehrlich Ascites. Species: Mouse. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:100.</p>

Immunohistochemistry analysis using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Tissue: Ehrlich Ascites. Species: Mouse. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:100.

<p>Western blot analysis of Human COLO cell lysates showing detection of ~17kDa Caspase 3 protein using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Lane 1: Human COLO cell lysate treated with the immunizing peptide. Lane 2: Human COLO cell lysate. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:1000. Predicted/Observed Size: ~17kDa.</p>

Western blot analysis of Human COLO cell lysates showing detection of ~17kDa Caspase 3 protein using Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319). Lane 1: Human COLO cell lysate treated with the immunizing peptide. Lane 2: Human COLO cell lysate. Primary Antibody: Rabbit Anti-Caspase 3 Polyclonal Antibody (SPC-1319) at 1:1000. Predicted/Observed Size: ~17kDa.

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  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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