StressMarq/C16/SIH-498-5MG/5-mg
商品编号：
SIH-498-5MG
市场价：
¥1300.00
美元价：
780.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | C16 |
| Description | PKR kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 608512-97-6 |
| Molecular Formula | C13H8N4OS |
| Molecular Weight | 268.3 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO 12 mg/ml |
| Source | Synthetic |
| Appearance | Solid |
| SMILES | C1=CC2=C(C3=C1NC(=O)/C3=CC4=CNC=N4)SC=N2 |
| InChI | InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3+ |
| InChIKey | VFBGXTUGODTSPK-FPYGCLRLSA-N |
| Safety Phrases | Classification: Chronic aquatic toxicity (Category 4), H413Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.Hazard statements: H413 May cause long lasting harmful effects to aquatic life.Precautionary statements: P273 Avoid release to the environment. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | C16 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-498) |
Biological Description
| Alternative Names | Imidazolo-oxindole PKR inhibitor C16, 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one |
| Research Areas | Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 67016828 |
| Scientific Background | C16 is a derivative of imidazolo-oxindole and inhibits RNA-dependent protein kinases (PKR). Its inhibition effect on PKR is ATP-binding site directed. C16 has been shown to specifically inhibit the apoptotic PKR/eIF2a signaling pathway. |
| References |
1. Couturier J., et al. (2010) J. Biol. Chem. 285(2): 1272–1282. 2. Jammi N.V., Whitby L.R., & Beal P.A. (2003) Biochem. Biophys.Res. Comm. 308(1):50–57. |
Product Images
Chemical structure of C16 (SIH-498), a PKR kinase inhibitor. CAS #: 608512-97-6. Molecular Formula: C13H8N4OS. Molecular Weight: 268.3 g/mol.
Product Citations (0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
