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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-BubR1 Antibody (pSer670)/SPC-929D-A488/100-µl
商品详细StressMarq/Anti-BubR1 Antibody (pSer670)/SPC-929D-A488/100-µl
StressMarq/Anti-BubR1 Antibody (pSer670)/SPC-929D-A488/100-µl
StressMarq/Anti-BubR1 Antibody (pSer670)/SPC-929D-A488/100-µl
商品编号: SPC-929D-A488
市场价: ¥6840.00
美元价: 4104.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

Product Name BubR1 Antibody (pSer670)
Description

Rabbit Anti-Human BubR1 (pSer670) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Ser670 of human BUBR1 (AA667-673)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 119 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-929, RRID: AB_2707121
Certificate of Analysis A 1:250 dilution of SPC-929 was sufficient for detection of BubR1 (pSer670) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names Beta homolg of S. cerevisiae BUB 1 antibody, Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody, BUB 1B antibody, BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody, Bub1A antibody, BUB1B antibody, BUB1B_HUMAN antibody, BUB1beta antibody, BUBR1 antibody, Budding Uninhibited by Benzimidazoles 1 beta antibody, Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody, hBUBR1 antibody, MAD3/BUB1 related protein kinase antibody, MAD3L antibody, Mitotic checkpoint gene BUB1B antibody, Mitotic checkpoint kinase MAD3L antibody, MVA1 antibody, Protein SSK1 antibody, SSK 1 antibody, SSK1 antibody
Research Areas Cancer, Cell Cycle, Cell Division, Cell Signaling, Epigenetics and Nuclear Signaling, Protein Phosphorylation
Cellular Localization Cytoplasm, Nucleus
Accession Number NP_001202
Gene ID 701
Swiss Prot O60566
Scientific Background BUBR1 is a protein-serine/threonine kinase. It is an essential component of mitotic checkpoint. It prevents progression of anaphase until all the sister chomatids are connected to spindles by binding to CDC20 to anaphase promoting complex/cycolsome thus inhibiting it. It is also involved in localization of CENPE, a kinetochore motor that performs kinetochore functions. Other functions include suppression of centrosome amplification, negative regulation of PLK1 in intephase and trigger apoptosis in polyploid cells.

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  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。