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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-BTK Antibody (pTyr223 + pTyr225)/SPC-928D-A488/100-µl
商品详细StressMarq/Anti-BTK Antibody (pTyr223 + pTyr225)/SPC-928D-A488/100-µl
StressMarq/Anti-BTK Antibody (pTyr223 + pTyr225)/SPC-928D-A488/100-µl
StressMarq/Anti-BTK Antibody (pTyr223 + pTyr225)/SPC-928D-A488/100-µl
商品编号: SPC-928D-A488
市场价: ¥6840.00
美元价: 4104.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

Product Name BTK Antibody (pTyr223 + pTyr225)
Description

Rabbit Anti-Human BTK (pTyr223 + pTyr225) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:1000); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Tyr223 and Tyr225 of human BTK (AA220-226)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 76.281 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-928, RRID: AB_2707103
Certificate of Analysis A 1:250 dilution of SPC-928 was sufficient for detection of BTK (pTyr223 + pTyr225) in 10 µg of HEK293 cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names Agammaglobulinaemia tyrosine kinase Antibody, AGMX1 Antibody, ATK Antibody, B cell progenitor kinase Antibody, Bruton tyrosine kinase Antibody, IMD 1 Antibody, PSCTK1 Antibody, Tyrosine protein kinase BTK Antibody
Research Areas Cell Signaling, Immunology, Innate Immunity, Protein Phosphorylation, TLR Signaling, Tyrosine Kinases
Cellular Localization Cytoplasm, Membrane, Nucleus
Accession Number NP_000052
Gene ID 695
Swiss Prot Q06187
Scientific Background BTK is a cytoplasmic protein-tyrosine kinase, involved in B cell development, differentiation and signalling. It is a downstream target of the B-cell receptor and plays an important role in immune cell related pathways. BTK has a dual function in apoptosis. Not reported to directly interact with DNA. Expression of a truncated BTK variant in leukemia, which mediates phosphorylation and activation of normal BTK by BCR-ABL1. Constitutively activated BTK promotes cell survival.

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  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。