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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-BIM/BOD (IN) Antibody/SPC-113D-A390/100-µg
商品详细StressMarq/Anti-BIM/BOD (IN) Antibody/SPC-113D-A390/100-µg
StressMarq/Anti-BIM/BOD (IN) Antibody/SPC-113D-A390/100-µg
StressMarq/Anti-BIM/BOD (IN) Antibody/SPC-113D-A390/100-µg
商品编号： SPC-113D-A390
市场价： ¥6120.00
美元价： 3672.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name BIM/BOD (IN) Antibody
Description

Rabbit Anti-Human BIM/BOD (IN) Polyclonal

Species Reactivity Human, Mouse, Rat
Applications WB, IHC
Antibody Dilution WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Internal central amino acids of human Bim
Concentration 1 mg/ml
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS, 50% glycerol, 0.09% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Protein A purified
Clonality Polyclonal
Specificity Detects ~23kDa.
Cite This Product StressMarq Biosciences Cat# SPC-113, RRID: AB_2290432
Certificate of Analysis 1 µg/ml of SPC-113 was sufficient for detection of Bim in 20 µg of K562 and A549 cell lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names BCL2 like protein 11 Antibody, Bcl2 interacting mediator of cell death Antibody, Bcl2 interacting protein Bim Antibody, BCL2 like 11 Antibody, BAM Antibody, BimEl Antibody, BimL Antibody, BOD Antibody, BIM beta 6 Antibody, BIM Beta7 Antibody, BIM alpha 3 Antibody, BIM alpha4 Antibody, BIM alpha5 Antibody, BIM alpha6 Antibody
Research Areas Cancer, Apoptosis
Cellular Localization Endomembrane system, Mitochondrion
Accession Number NP_619527.1
Gene ID 10018
Swiss Prot O43521
Scientific Background Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1 ,2).
References 1. O'Connor L., Strasser A., O'Reilly L.A., et al. (1998) EMBO J. 17: 384-395.
2. Hsu S.Y., Lin P., and Hsueh A.J. (1998) Mol. Endocrinol. 12: 1432-40.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-BIM Polyclonal Antibody (SPC-113). Tissue: skin cancer cells. Species: Human. Primary Antibody: Rabbit Anti-BIM Polyclonal Antibody (SPC-113) at 1:100.</p>

Immunohistochemistry analysis using Rabbit Anti-BIM Polyclonal Antibody (SPC-113). Tissue: skin cancer cells. Species: Human. Primary Antibody: Rabbit Anti-BIM Polyclonal Antibody (SPC-113) at 1:100.

<p>Western blot analysis of Human K562 (Left) and A549 (Right) whole cell lysates showing detection of BIM protein using Rabbit Anti-BIM Polyclonal Antibody (SPC-113). Primary Antibody: Rabbit Anti-BIM Polyclonal Antibody (SPC-113) at 1:1000.</p>

Western blot analysis of Human K562 (Left) and A549 (Right) whole cell lysates showing detection of BIM protein using Rabbit Anti-BIM Polyclonal Antibody (SPC-113). Primary Antibody: Rabbit Anti-BIM Polyclonal Antibody (SPC-113) at 1:1000.

Product Citations (1)

Western Blot

Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling.

Peperzak, V., Slinger, E., Ter Burg, J. and Eldering, E. (2016) Cell Death Differ. 24(1):111-119.

PubMed ID: 27689871 Reactivity Human Applications: Western Blot

  ATTO 390
Overview:

  • High fluorescence yield
  • Large Stokes-shift (89 nm)
  • Good photostability
  • Moderately hydrophilic
  • Good solubility in polar solvents
  • Coumarin derivate, uncharged
  • Low molar mass: 343.42 g/mol 

ATTO 390 Datasheet

ATTO 390 Fluorescent Dye Excitation and Emission SpectraOptical Properties:

λex = 390 nm

λem = 479 nm

εmax = 2.4×104

Φf = 0.90

τfl = 5.0 ns

Brightness = 21.6

Laser = 365 or 405 nm

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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