StressMarq/Anti-BIM/BOD (IN) Antibody/SPC-113D/100-µg-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-BIM/BOD (IN) Antibody/SPC-113D/100-µg

StressMarq/Anti-BIM/BOD (IN) Antibody/SPC-113D/100-µg

商品编号： SPC-113D

品牌： StressMarq Biosciences

市场价： ¥5160.00

美元价： 3096.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName BIM/BOD(IN)Antibody

Description

RabbitAnti-HumanBIM/BOD(IN)Polyclonal

SpeciesReactivity Human,Mouse,Rat

Applications WB,IHC

AntibodyDilution WB(1:1000),IHC(1:100);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen InternalcentralaminoacidsofhumanBim

Concentration 1mg/ml

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBS,50%glycerol,0.09%sodiumazide
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	ProteinApurified
Clonality	Polyclonal
Specificity	Detects~23kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-113,RRID:AB_2290432
CertificateofAnalysis	1µg/mlofSPC-113wassufficientfordetectionofBimin20µgofK562andA549celllysatesbycolorimetricimmunoblotanalysisusingGoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	BCL2likeprotein11Antibody,Bcl2interactingmediatorofcelldeathAntibody,Bcl2interactingproteinBimAntibody,BCL2like11Antibody,BAMAntibody,BimElAntibody,BimLAntibody,BODAntibody,BIMbeta6Antibody,BIMBeta7Antibody,BIMalpha3Antibody,BIMalpha4Antibody,BIMalpha5Antibody,BIMalpha6Antibody
ResearchAreas	Cancer,Apoptosis
CellularLocalization	Endomembranesystem,Mitochondrion
AccessionNumber	NP_619527.1
GeneID	10018
SwissProt	O43521
ScientificBackground	MembersintheBcl-2familyarecriticalregulatorsofapoptosisbyeitherinhibitingorpromotingcelldeath.Bim/BODisagroupofthreesplicevariants,BimEL,BimLandBimS,withapparentmolecularmassesof~23,16,and13kDa,respectively.Bcl-2homology3(BH3)domainisapotentdeathdomain.BH3domaincontainingpro-apoptoticproteins,includingBad,Bax,Bid,Bik,andHrk,formagrowingsubclassoftheBcl-2family.AnovelBH3domaincontainingproteinwasrecentlyidentifiedanddesignatedBimorBODinhuman,mouseandrat(1,2).Bim/BODinteractswithdiversemembersinthepro-survivalBcl-2sub-familyincludingBcl-2,Bcl-xLandBcl-w.Bim/BODinducesapoptosis.ThemessengerRNAofBimisubiquitouslyexpressedinmultipletissuesandcelllines(1,2).
References	1.O"ConnorL.,StrasserA.,O"ReillyL.A.,etal.(1998)EMBOJ.17:384-395. 2.HsuS.Y.,LinP.,andHsuehA.J.(1998)Mol.Endocrinol.12:1432-40.

ProductImages

<p>Immunohistochemistry analysis using Rabbit Anti-BIM Polyclonal Antibody (SPC-113). Tissue: skin cancer cells. Species: Human. Primary Antibody: Rabbit Anti-BIM Polyclonal Antibody (SPC-113) at 1:100.</p>

ImmunohistochemistryanalysisusingRabbitAnti-BIMPolyclonalAntibody(SPC-113).Tissue:skincancercells.Species:Human.PrimaryAntibody:RabbitAnti-BIMPolyclonalAntibody(SPC-113)at1:100.

<p>Western blot analysis of Human K562 (Left) and A549 (Right) whole cell lysates showing detection of BIM protein using Rabbit Anti-BIM Polyclonal Antibody (SPC-113). Primary Antibody: Rabbit Anti-BIM Polyclonal Antibody (SPC-113) at 1:1000.</p>

WesternblotanalysisofHumanK562(Left)andA549(Right)wholecelllysatesshowingdetectionofBIMproteinusingRabbitAnti-BIMPolyclonalAntibody(SPC-113).PrimaryAntibody:RabbitAnti-BIMPolyclonalAntibody(SPC-113)at1:1000.

ProductCitations(1)

WesternBlot

FunctionaldisparitiesamongBCL-2membersintonsillarandleukemicB-cellsubsetsassessedbyBH3-mimeticprofiling.

Peperzak,V.,Slinger,E.,TerBurg,J.andEldering,E.(2016)CellDeathDiffer.24(1):111-119.

PubMedID:27689871ReactivityHumanApplications:WesternBlot

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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