StressMarq/BIBW 2992/SIH-496-25MG/25-mg
商品编号：
SIH-496-25MG
市场价：
¥10000.00
美元价：
6000.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | BIBW2992 |
| Description | EGFR,HER2kinaseinhibitor |
| Purity | >99% |
| CASNo. | 850140-72-6 |
| MolecularFormula | C24H25ClFN5O3 |
| MolecularWeight | 485.9 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSOat200mg/ml;inethanolat25mg/ml |
| Source | Synthetic |
| Appearance | Crystallinesolid |
| SMILES | CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4 |
| InChI | InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h4-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 |
| InChIKey | ULXXDDBFHOBEHA-CWDCEQMOSA-N |
| SafetyPhrases | Classification:AcuteToxicity:Oral,Category2SkinCorrosion/Irritation,Category2SeriousEyeDamage/EyeIrritation,Category1ToxicToReproduction,Category2TargetOrganSystemicToxicity(repeatedexposure),Category2SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H300:Fatalifswallowed.H315:Causesskinirritation.H318:Causesseriouseyedamage.H361:SUSPectedofdamagingfertilityortheunbornchild.H373:Maycausedamagethroughprolongedorrepeatedexposure.Precautionarystatements:P264:Wash{hands}thoroughlyafterhandling.P280:Wear{protectivegloves/protectiveclothing/eyeprotection/faceprotection}.P362+364:Takeoffcontaminatedclothingandwashitbeforereuse.P201:Obtainspecialinstructionsbeforeuse.P202:Donothandleuntilallsafetyprecautionshavebeenreadandunderstood.P281:Usepersonalprotectiveequipmentasrequired.P260:Donotbreathe{dust/fume/gas/mist/vapours/spray}.P301+310:IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physician.P330:Rinsemouth.P302+352:IFONSKIN:Washwithplentyofsoapandwater.P332+313:Ifskinirritationoccurs,getmedicaladvice/attention.P305+351+338:IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P310:Immediatelycalla{POISONCENTER/doctor/...}.P308+313:IFexposedorconcerned:Getmedicalattentiodvice.P314:Getmedicalattentiodviceifyoufeelunwell. |
| CiteThisProduct | BIBW2992(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-496) |
BIOLOGicalDescription
| AlternativeNames | Afatinib,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 10184653 |
| ScientificBackground | BIBW2992isapotentandirreversIBLeErbBinhibitor.IthasalsobeenshowntoinhibitEGFR/Neu. |
| References | 1.Ioannou,N.,etal.(2011)Br.J.Cancer.105(10):1554–1562. |
ProductImages
ChemicalstructureofBIBW2992(SIH-496),aEGFRandHER2kinaseinhibitor.CAS#:439081-18-2.MolecularFormula:C24H25ClFN5O3.MolecularWeight:485.9g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
