StressMarq/Bafilomycin A1/SIH-391-500UG/500-µg
商品编号：
SIH-391-500UG
市场价：
¥2000.00
美元价：
1200.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | Bafilomycin A1 |
| Description | Autophagy inhibitor |
| Purity | >95% |
| CAS No. | 88899-55-2 |
| Molecular Formula | C35H58O9 |
| Molecular Weight | 622.84 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 100% ethanol, methanol or DMSO. |
| Source | Synthetic |
| Appearance | White powder to colorless film. |
| SMILES | [[email protected]]1(O[[email protected]@H]([[email protected]]([[email protected]](O)C1)C)C(C)C)(O)[[email protected]]([[email protected]](O)[[email protected]@H]([[email protected]]2OC(=O)C(=C/C(=C/[[email protected]]([[email protected]@H](O)[[email protected]](CC(=C/C=C/[[email protected]@H]2OC) |
| InChI | InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H |
| InChIKey | XDHNQDDQEHDUTM-JQWOJBOSSA-N |
| Safety Phrases | Classification: D2B- Toxic Material Causing Other Toxic Effects Irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315- Causes skin irritation. H319- Causes serious eye irritation. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash skin thoroughly after handling. P271- Use only outdoors or in a well-ventilated area. P280- Wear protective gloves/ eye protection/ face protection. P302 + P352- IF ON SKIN: Wash with plenty of soap and water. P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312- Call a POISON CENTER or doctor/ physician if you feel unwell. P321- Specific treatment (see supplemental first aid instructions on this label). P332 + P313- If skin irritation occurs: Get medical advice/ attention. P337 + P313- If eye irritation persists: Get medical advice/ attention. P362- Take off contaminated clothing and wash before reuse. P403 + P233- Store in a well-ventilated place. Keep container tightly closed. P405- Store locked up. P501- Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Bafilomycin A1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-391) |
Biological Description
| Alternative Names | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one |
| Research Areas | Cancer, Autophagy |
| PubChem ID | 6436223 |
| Scientific Background | Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation. |
| References |
1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212. 2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16. 3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42. |
Product Images
Chemical structure of Bafilomycin A1 (SIH-391), a Autophagy inhibitor. CAS #: 88899-55-2. Molecular Formula: C35H58O9. Molecular Weight: 622.84 g/mol.
Product Citations (0)
Currently there are no citations for this product.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
